| Literature DB >> 11948855 |
C B Chen1, L Milne, R Landgraf, D M Perrin, D S Sigman.
Abstract
The oxidation of DNA and RNA provides a facile approach for investigating the interaction of nucleic acids with proteins and oligonucleotides. In this article, we have outlined our understanding of the mechanism of DNA scission by 1,10-phenanthroline-copper(I) in the presence of hydrogen peroxide. We also discuss results obtained by using 1,10-phenanthroline-oligonucleotide conjugates in probing the size of the transcriptionally active open complex. Finally, we outline an effective method for converting DNA-binding proteins into site-specific modification agents by using 1,10-phenanthroline-copper(I).Entities:
Mesh：
Substances：
Year: 2001 PMID： 11948855 DOI： 10.1002/1439-7633(20011001)2:10<735::aid-cbic735>3.0.co;2-#
Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164