Literature DB >> 11943480

MERP1: a mammalian ependymin-related protein gene differentially expressed in hematopoietic cells.

Claudia C Gregorio-King1, Janet L McLeod, Fiona McL Collier, Gregory R Collier, Karyn A Bolton, Gavin J Van Der Meer, Jim Apostolopoulos, Mark A Kirkland.   

Abstract

We have utilized differential display polymerase chain reaction to investigate the gene expression of hematopoietic progenitor cells from adult bone marrow and umbilical cord blood. A differentially expressed gene was identified in CD34+ hematopoietic progenitor cells, with low expression in CD34- cells. We have obtained the full coding sequence of this gene which we designated human mammalian ependymin-related protein 1 (MERP1). Expression of MERP1 was found in a variety of normal human tissues, and is 4- and 10-fold higher in adult bone marrow and umbilical cord blood CD34+ cells, respectively, compared to CD34- cells. Additionally, MERP1 expression in a hematopoietic stem cell enriched population was down-regulated with proliferation and differentiation. Conceptual translation of the MERP1 open reading frame reveals significant homology to two families of glycoprotein calcium-dependant cell adhesion molecules: ependymins and protocadherins.

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Year:  2002        PMID： 11943480     DOI： 10.1016/s0378-1119(02)00434-1

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  10 in total

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Journal:  Nat Genet       Date:  2016-04-04       Impact factor: 38.330

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4.  Alteration of Gene Expression Profile in Kidney of Spontaneously Hypertensive Rats Treated with Protein Hydrolysate of Blue Mussel (Mytilus edulis) by DNA Microarray Analysis.

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5.  The evolution of ependymin-related proteins.

Authors:  Carmel McDougall; Michael J Hammond; Simon C Dailey; Ildiko M L Somorjai; Scott F Cummins; Bernard M Degnan
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6.  Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.

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7.  EPDR1, Which Is Negatively Regulated by miR-429, Suppresses Epithelial Ovarian Cancer Progression via PI3K/AKT Signaling Pathway.

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9.  EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness.

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  10 in total

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