Literature DB >> 11942698

The effects of immunization against cholecystokinin fragment 30-33 in the behavior of white rats.

R A Danilova1, O I Rud'ko, T M Korotkova, M F Obukhova, I P Ashmarin.   

Abstract

Active immunization of white rats with cholecystokinin-4 covalently linked to the antigen carrier BSA evoked long-lasting changes in the rats' behavior, which were in the opposite direction to the anxiogenic effects of cholecystokinin-4 itself, showing that immunization had anxiolytic effects. Immunoenzyme analysis demonstrated the presence of antibodies to cholecystokinin-4 in the serum of immunized rats. These data are interesting from the point of view of correcting pathological anxiety and fear states by inverse immunoregulation.

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Year:  2002        PMID： 11942698     DOI： 10.1023/a:1013983626780

Source DB:  PubMed          Journal:  Neurosci Behav Physiol        ISSN： 0097-0549


  16 in total

1.  Behavioral, cardiovascular, and neuroendocrine profiles following CCK-4 challenge in healthy volunteers: a comparison of panickers and nonpanickers.

Authors:  D Koszycki; R M Zacharko; J M Le Mellédo; J Bradwejn
Journal:  Depress Anxiety       Date:  1998       Impact factor: 6.505

2.  [Assessment of the psychotropic activity of analogs of cholecystokinin tetrapeptide fragment].

Authors:  I P Anokhina; Zh D Bespalova; T V Proskuriakova; N V Pankratova; M E Pal'keeva; O B Petrichenko
Journal:  Biull Eksp Biol Med       Date:  1998-06

3.  Decrease in short-term memory function induced by CCK-4 in healthy volunteers.

Authors:  J Shlik; D Koszycki; J Bradwejn
Journal:  Peptides       Date:  1998       Impact factor: 3.750

4.  Cellular immune reactions and blood cerebrospinal fluid barrier dysfunction in guinea pigs.

Authors:  H Reiber; B Kitze; M Link; R Wagner
Journal:  Neurochem Res       Date:  1988-05       Impact factor: 3.996

Review 5.  Saturable transport of peptides across the blood-brain barrier.

Authors:  W A Banks; A J Kastin
Journal:  Life Sci       Date:  1987-09-14       Impact factor: 5.037

Review 6.  [The inverse immunoregulation of behavior and the problem of the existence of regulatory autoantibodies].

Authors:  R A Danilova; I P Ashmarin
Journal:  Usp Fiziol Nauk       Date:  1994 Jan-Mar

7.  In mononeuropathic rats, the enhancement of morphine antinociception by L-365,260, a selective CCK(B) receptor antagonist, depends on the dose of systemic morphine and stimulus characteristics.

Authors:  J J Idänpään-Heikkilä; S Perrot; G Guilbaud; V Kayser
Journal:  Eur J Pharmacol       Date:  1997-05-01       Impact factor: 4.432

8.  Memory effect of caerulein and its analogs in active and passive avoidance responses in the rat.

Authors:  S Itoh; A Takashima; K Igano; K Inouye
Journal:  Peptides       Date:  1989 Jul-Aug       Impact factor: 3.750

9.  Macromolecular permeability across the blood-nerve and blood-brain barriers.

Authors:  J F Poduslo; G L Curran; C T Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

Review 10.  Major biological actions of CCK--a critical evaluation of research findings.

Authors:  H Fink; A Rex; M Voits; J P Voigt
Journal:  Exp Brain Res       Date:  1998-11       Impact factor: 1.972
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  1 in total

1.  Long-lasting changes of albino rats behavior and brain bioamines content after immunization against cholecystokinin-3 and -4.

Authors:  Igor Petrovich Ashmarin; Raisa A Danilova; Maria F Obukhova; Olga Igorevna Rud'ko; Ludmila A Andreeva
Journal:  Neurochem Res       Date:  2007-03       Impact factor: 3.996
  1 in total

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