| Literature DB >> 11934588 |
J I Levin1, J M Chen, M T Du, F C Nelson, L M Killar, S Skala, A Sung, G Jin, R Cowling, D Barone, C J March, K M Mohler, R A Black, J S Skotnicki.
Abstract
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing novel acetylenic P1' groups was explored. In particular, compound 4t bearing a butynyloxy P1' moiety has excellent in vitro potency against isolated TACE enzyme and in cells, good selectivity over MMP-1 and oral activity in an in vivo model of TNF-alpha production.Entities:
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Year: 2002 PMID： 11934588 DOI： 10.1016/s0960-894x(02)00136-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823