Literature DB >> 11934584

Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir).

Hing L Sham1, David A Betebenner, Xiaoqi Chen, Ayda Saldivar, Sudthida Vasavanonda, Dale J Kempf, Jacob J Plattner, Daniel W Norbeck.   

Abstract

The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2' position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure-activity relationships explored.

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Year:  2002        PMID： 11934584     DOI： 10.1016/s0960-894x(02)00134-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction.

Authors:  Tummala R K Reddy; Chan Li; Peter M Fischer; Lodewijk V Dekker
Journal:  ChemMedChem       Date:  2012-05-29       Impact factor: 3.466

2.  Selective phenol methylation to 2,6-dimethylphenol in a fluidized bed of iron-chromium mixed oxide catalyst with o-cresol circulation.

Authors:  Witold Zukowski; Gabriela Berkowicz; Jerzy Baron; Stanisław Kandefer; Dariusz Jamanek; Stefan Szarlik; Zbigniew Wielgosz; Maria Zielecka
Journal:  Chem Cent J       Date:  2014-09-16       Impact factor: 4.215

3.  Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction.

Authors:  Tummala R K Reddy; Chan Li; Xiaoxia Guo; Peter M Fischer; Lodewijk V Dekker
Journal:  Bioorg Med Chem       Date:  2014-08-07       Impact factor: 3.641

4.  Synthesis and Characterization of Impurities in the Production Process of Lopinavir.

Authors:  Ambati V Raghava Reddy; Srinivas Garaga; Chandiran Takshinamoorthy; Andra Naidu
Journal:  Sci Pharm       Date:  2014-09-22

5.  Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin.

Authors:  Abdelsattar M Omar; Mona A Mahran; Mohini S Ghatge; Faida H A Bamane; Mostafa H Ahmed; Moustafa E El-Araby; Osheiza Abdulmalik; Martin K Safo
Journal:  Molecules       Date:  2016-08-13       Impact factor: 4.411
  5 in total

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