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Literature DB >> 11934573

An efficient chemical synthesis of nicotinamide riboside (NAR) and analogues.

Shinji Tanimori¹, Takeshi Ohta, Mitsunori Kirihata.

Abstract

A simple and efficient synthesis of nicotinamide riboside (NAR) 1 and derivatives 4 and 5 via trimethylsilyl trifluoromethanesulfonate (TMSOTf)-mediated N-glycosilation followed by spontaneous deacetylation by treating with methanol is reported.

Entities: Chemical Disease Gene

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Year: 2002 PMID： 11934573 DOI： 10.1016/s0960-894x(02)00125-7

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

Review 1. The chemistry of the vitamin B3 metabolome.

Authors: Mikhail V Makarov; Samuel A J Trammell; Marie E Migaud
Journal: Biochem Soc Trans Date: 2018-12-17 Impact factor: 5.407

2. Chemoenzymatic Preparation of 4'-Thioribose NAD^.

Authors: Xiao-Nan Zhang; Zhefu Dai; Qinqin Cheng; Yong Zhang
Journal: Curr Protoc Nucleic Acid Chem Date: 2019-04-05

3. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway.

Authors: S Chlopicki; J Swies; A Mogielnicki; W Buczko; M Bartus; M Lomnicka; J Adamus; J Gebicki
Journal: Br J Pharmacol Date: 2007-07-16 Impact factor: 8.739

An efficient chemical synthesis of nicotinamide riboside (NAR) and analogues.

Review 1. The chemistry of the vitamin B3 metabolome.

2. Chemoenzymatic Preparation of 4'-Thioribose NAD^.

3. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway.

4. Chemo-enzymatic synthesis of isotopically labeled nicotinamide riboside.

5. Synthesis of β-Nicotinamide Riboside Using an Efficient Two-Step Methodology.

Review 6. Emerging Role of Nicotinamide Riboside in Health and Diseases.

7. New Crystalline Salts of Nicotinamide Riboside as Food Additives.

An efficient chemical synthesis of nicotinamide riboside (NAR) and analogues.

Review 1. The chemistry of the vitamin B3 metabolome.

2. Chemoenzymatic Preparation of 4'-Thioribose NAD.

3. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway.

4. Chemo-enzymatic synthesis of isotopically labeled nicotinamide riboside.

5. Synthesis of β-Nicotinamide Riboside Using an Efficient Two-Step Methodology.

Review 6. Emerging Role of Nicotinamide Riboside in Health and Diseases.

7. New Crystalline Salts of Nicotinamide Riboside as Food Additives.

2. Chemoenzymatic Preparation of 4'-Thioribose NAD^.