Literature DB >> 11931569

An overview of toxicogenomics.

Hisham K Hamadeh1, Rupesh P Amin, Richard S Paules, Cynthia A Afshari.   

Abstract

Toxicogenomics is a rapidly developing discipline that promises to aid scientists in understanding the molecular and cellular effects of chemicals in biological systems. This field encompasses global assessment of biological effects using technologies such as DNA microarrays or high throughput NMR and protein expression analysis. This review provides an overview of advancing multiple approaches (genomic, proteomic, metabonomic) that may extend our understanding of toxicology and highlights the importance of coupling such approaches with classical toxicity studies.

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Year:  2002        PMID： 11931569

Source DB:  PubMed          Journal:  Curr Issues Mol Biol        ISSN： 1467-3037            Impact factor:   2.081


  14 in total

1.  Expression of copper-responsive genes in HepG2 cells.

Authors:  Min Ok Song; Jonathan H Freedman
Journal:  Mol Cell Biochem       Date:  2005-11       Impact factor: 3.396

Review 2.  From Classical Toxicology to Tox21: Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning From the Last Quarter of the 20th Century.

Authors:  Supratim Choudhuri; Geoffrey W Patton; Ronald F Chanderbhan; Antonia Mattia; Curtis D Klaassen
Journal:  Toxicol Sci       Date:  2018-01-01       Impact factor: 4.849

3.  Discovery of characteristic molecular signatures for the simultaneous prediction and detection of environmental pollutants.

Authors:  Mi-Kyung Song; Han-Seam Choi; Yong-Keun Park; Jae-Chun Ryu
Journal:  Environ Sci Pollut Res Int       Date:  2013-11-07       Impact factor: 4.223

Review 4.  Functional toxicogenomics: mechanism-centered toxicology.

Authors:  Matthew North; Chris D Vulpe
Journal:  Int J Mol Sci       Date:  2010-11-24       Impact factor: 5.923

5.  Successful drug development despite adverse preclinical findings part 2: examples.

Authors:  Robert A Ettlin; Junji Kuroda; Stephanie Plassmann; Makoto Hayashi; David E Prentice
Journal:  J Toxicol Pathol       Date:  2010-12-16       Impact factor: 1.628

6.  Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology.

Authors:  Sandra C Dos Santos; Miguel Cacho Teixeira; Tânia R Cabrito; Isabel Sá-Correia
Journal:  Front Genet       Date:  2012-04-19       Impact factor: 4.599

7.  Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers.

Authors:  Matthew S Forrest; Qing Lan; Alan E Hubbard; Luoping Zhang; Roel Vermeulen; Xin Zhao; Guilan Li; Yen-Ying Wu; Min Shen; Songnian Yin; Stephen J Chanock; Nathaniel Rothman; Martyn T Smith
Journal:  Environ Health Perspect       Date:  2005-06       Impact factor: 9.031

Review 8.  ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research.

Authors:  Weida Tong; Xiaoxi Cao; Stephen Harris; Hongmei Sun; Hong Fang; James Fuscoe; Angela Harris; Huixiao Hong; Qian Xie; Roger Perkins; Leming Shi; Dan Casciano
Journal:  Environ Health Perspect       Date:  2003-11       Impact factor: 9.031

Review 9.  Functional toxicology: tools to advance the future of toxicity testing.

Authors:  Brandon D Gaytán; Chris D Vulpe
Journal:  Front Genet       Date:  2014-05-05       Impact factor: 4.599

10.  Designing toxicogenomics studies that use DNA array technology.

Authors:  Robert R Delongchamp; Cruz Velasco; Varsha G Desai; Taewon Lee; James C Fuscoe
Journal:  Bioinform Biol Insights       Date:  2008-08-14
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