Literature DB >> 11930909

Alzheimer's disease research enters a "new cycle": how significant?

A Copani1, M A Sortino, F Nicoletti, Stella A M Giuffrida.   

Abstract

Recent evidence suggests a link between the aberrant re-expression of cell cycle proteins in adult neurons of the Alzheimer's disease brain and the process of apoptotic degeneration. Here we will discuss this unexpected phenomenon as related to the mechanisms of beta-amyloid toxicity, and its significance for therapeutic possibilities.

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Year:  2002        PMID： 11930909     DOI： 10.1023/a:1014879311761

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  35 in total

Review 1.  Mechanisms of neuronal degeneration in Alzheimer's disease.

Authors:  B A Yankner
Journal:  Neuron       Date:  1996-05       Impact factor: 17.173

2.  Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease.

Authors:  T Arendt; L Rödel; U Gärtner; M Holzer
Journal:  Neuroreport       Date:  1996-11-25       Impact factor: 1.837

3.  Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

Authors:  A McShea; P L Harris; K R Webster; A F Wahl; M A Smith
Journal:  Am J Pathol       Date:  1997-06       Impact factor: 4.307

4.  Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions.

Authors:  Z Nagy; M M Esiri; A D Smith
Journal:  Acta Neuropathol       Date:  1997-03       Impact factor: 17.088

Review 5.  Eukaryotic DNA polymerases, a growing family.

Authors:  U Hübscher; H P Nasheuer; J E Syväoja
Journal:  Trends Biochem Sci       Date:  2000-03       Impact factor: 13.807

6.  Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

Authors:  J Busser; D S Geldmacher; K Herrup
Journal:  J Neurosci       Date:  1998-04-15       Impact factor: 6.167

Review 7.  A matter of life and cell death.

Authors:  G Evan; T Littlewood
Journal:  Science       Date:  1998-08-28       Impact factor: 47.728

8.  p53 expression in brain after middle cerebral artery occlusion in the rat.

Authors:  M Chopp; Y Li; Z G Zhang; S O Freytag
Journal:  Biochem Biophys Res Commun       Date:  1992-02-14       Impact factor: 3.575

9.  Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons.

Authors:  D S Park; B Levine; G Ferrari; L A Greene
Journal:  J Neurosci       Date:  1997-12-01       Impact factor: 6.167

10.  Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.

Authors:  C W Wong; V Quaranta; G G Glenner
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205
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  3 in total

Review 1.  Cell cycle molecules define a pathway required for neuron death in development and disease.

Authors:  Lloyd A Greene; David X Liu; Carol M Troy; Subhas C Biswas
Journal:  Biochim Biophys Acta       Date:  2006-12-13

2.  Cell cycle activation and CNS injury.

Authors:  Bogdan A Stoica; Kimberly R Byrnes; Alan I Faden
Journal:  Neurotox Res       Date:  2009-04-21       Impact factor: 3.911

3.  Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease.

Authors:  Hongwen He; Weiguo Dong; Fang Huang
Journal:  Curr Neuropharmacol       Date:  2010-09       Impact factor: 7.363
  3 in total

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