| Literature DB >> 11926861 |
Jan A M van Laar1, Corinne M P Buysse, Ann C T M Vossen, Björn Hjálmarsson, Bart van Den Berg, Kirsten van Lom, Jaap Deinum.
Abstract
We describe 2 immunocompetent adolescents with fulminant infectious mononucleosis and virus-associated hemophagocytosis. A new quantitative polymerase chain reaction revealed high serum Epstein-Barr virus DNA levels in these patients. One patient died with an increasing viral load not responding to corticosteroids followed by antiviral and intensified immunomodulatory treatment. The other patient received corticosteroids and acyclovir at diagnosis; her rapid recovery was heralded by a steep decline of viral load. We propose monitoring the clinical course of fulminant infectious mononucleosis in immunocompetent patients by Epstein-Barr virus DNA quantification and prompt corticosteroid and antiviral therapy when viral load is high.Entities:
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Year: 2002 PMID： 11926861 DOI： 10.1001/archinte.162.7.837
Source DB: PubMed Journal: Arch Intern Med ISSN： 0003-9926