Literature DB >> 1191435

Candida endocarditis treated with a combination of antifungal chemotherapy and aortic valve replacement.

D L Stone.   

Abstract

A case of Candida albicans endocarditis is described in which treatment with 5-fluorocytosine was started after aortic valve replacement, but relapse followed discontinuance of treatment. At a second operation the aortic valve was replaced under 5-fluorocytosine cover and treatment was continued with both 5-fluorocytosine and amphotericin-B. No resistance to 5-fluorocytosine developed, and the candida infection was eradicated. The patient is well 22 months after his operation.

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Year:  1975        PMID： 1191435      PMCID： PMC482938          DOI： 10.1136/hrt.37.11.1191

Source DB:  PubMed          Journal:  Br Heart J        ISSN： 0007-0769


  11 in total

1.  C. albicans resistance to 5-fluorocytosine.

Authors:  R L Logan; M J Goldberg
Journal:  Br Med J       Date:  1972-08-26

2.  The combined effect of 5-fluorocytosine and amphotericin B in the therapy of murine cryptococcosis.

Authors:  E R Block; J E Bennett
Journal:  Proc Soc Exp Biol Med       Date:  1973-02

Review 3.  Candida endocarditis after cardiac surgery. Clues to earlier detection.

Authors:  M S Seelig; C P Speth; P J Kozinn; E F Toni; C L Taschdjian
Journal:  J Thorac Cardiovasc Surg       Date:  1973-04       Impact factor: 5.209

4.  Patterns of Candida endocarditis following cardiac surgery: Importance of early diagnosis and therapy (an analysis of 91 cases).

Authors:  M S Seelig; C P Speth; P J Kozinn; C L Taschdjian; E F Toni; P Goldberg
Journal:  Prog Cardiovasc Dis       Date:  1974 Sep-Oct       Impact factor: 8.194

5.  Fungal endocarditis secondary to drug addiction. Recent concepts in diagnosis and therapy.

Authors:  P D Harris; C B Yeoh; J Breault; J Meltzer; S Katz
Journal:  J Thorac Cardiovasc Surg       Date:  1972-06       Impact factor: 5.209

6.  Synergistic action of amphotericin B and 5-fluorocytosine against yeast-like organisms.

Authors:  G Medoff; M Comfort; G S Kobayashi
Journal:  Proc Soc Exp Biol Med       Date:  1971-11

7.  Treatment of disseminated mycotic infectioons. A new approach to amphotericin B therapy.

Authors:  D J Drutz; A Spickard; D E Rogers; M G Koenig
Journal:  Am J Med       Date:  1968-09       Impact factor: 4.965

8.  Candida endocarditis treated with 5-fluorocytosine.

Authors:  C O Record; J M Skinner; P Sleight; D C Speller
Journal:  Br Med J       Date:  1971-01-30

9.  Pharmacological studies with 5-fluorocytosine.

Authors:  E R Block; J E Bennett
Journal:  Antimicrob Agents Chemother       Date:  1972-06       Impact factor: 5.191

10.  Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism).

Authors:  G Medoff; G S Kobayashi; C N Kwan; D Schlessinger; P Venkov
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205
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  1 in total

Review 1.  Fungal endocarditis: patients at risk and their treatment.

Authors:  M S Seelig; P J Kozinin; P Goldberg; A R Berger
Journal:  Postgrad Med J       Date:  1979-09       Impact factor: 2.401
  1 in total

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