Literature DB >> 11909726

5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

Yves P Auberson1, Hans Allgeier, Serge Bischoff, Kurt Lingenhoehl, Robert Moretti, Markus Schmutz.   

Abstract

NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1A/2A over 1A/2B subunit composition was optimized, leading to (1RS,1'S)-PEAQX (9r), which shows a >100-fold selectivity.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11909726     DOI： 10.1016/s0960-894x(02)00074-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  107 in total

1.  Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4.

Authors:  Yelin Chen; Yuanyuan Wang; Zora Modrusan; Morgan Sheng; Joshua S Kaminker
Journal:  J Neurosci       Date:  2014-11-12       Impact factor: 6.167

Review 2.  Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators.

Authors:  Daniel T Monaghan; Mark W Irvine; Blaise Mathias Costa; Guangyu Fang; David E Jane
Journal:  Neurochem Int       Date:  2012-01-17       Impact factor: 3.921

3.  Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors.

Authors:  Mark W Irvine; Blaise M Costa; Arturas Volianskis; Guangyu Fang; Laura Ceolin; Graham L Collingridge; Daniel T Monaghan; David E Jane
Journal:  Neurochem Int       Date:  2012-01-13       Impact factor: 3.921

4.  Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors.

Authors:  Rashna Balsara; Neill Li; Danielle Weber-Adrian; Louxiu Huang; Francis J Castellino
Journal:  Neuropharmacology       Date:  2012-01-27       Impact factor: 5.250

5.  Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits.

Authors:  Konkallu Hanumae Gowd; Tiffany S Han; Vernon Twede; Joanna Gajewiak; Misty D Smith; Maren Watkins; Randall J Platt; Gabriela Toledo; H Steve White; Baldomero M Olivera; Grzegorz Bulaj
Journal:  Biochemistry       Date:  2012-05-30       Impact factor: 3.162

Review 6.  Ionotropic and metabotropic glutamate receptor structure and pharmacology.

Authors:  James N C Kew; John A Kemp
Journal:  Psychopharmacology (Berl)       Date:  2005-02-25       Impact factor: 4.530

7.  Tonic activation of NMDA receptors by ambient glutamate of non-synaptic origin in the rat hippocampus.

Authors:  Karim Le Meur; Micaela Galante; María Cecilia Angulo; Etienne Audinat
Journal:  J Physiol       Date:  2006-12-21       Impact factor: 5.182

8.  Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat.

Authors:  Guy A Higgins; Theresa M Ballard; Michel Enderlin; Marie Haman; John A Kemp
Journal:  Psychopharmacology (Berl)       Date:  2005-03-10       Impact factor: 4.530

9.  Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.

Authors:  Shuijin He; Li-Rong Shao; Yu Wang; Suzanne B Bausch
Journal:  J Neurophysiol       Date:  2012-12-19       Impact factor: 2.714

10.  NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity.

Authors:  Jacqueline de Marchena; Adam C Roberts; Paul G Middlebrooks; Vera Valakh; Koji Yashiro; Lindsey R Wilfley; Benjamin D Philpot
Journal:  J Neurophysiol       Date:  2008-07-30       Impact factor: 2.714
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.