| Literature DB >> 11909706 |
Li-Ming Yang1, Shwu-Jiuan Lin, Fen-Lin Hsu, Tsang-Hsiung Yang.
Abstract
A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI(50)=0.205 microM) and HT-29 colon cancer (GI(50)=0.554 microM), respectively.Entities:
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Year: 2002 PMID： 11909706 DOI： 10.1016/s0960-894x(02)00092-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823