Literature DB >> 1190755

Fluid and penicillin G dynamics in polyethylene chambers implanted subcutaneously in rabbits.

R R Tight, R B Prior, R L Perkins, C A Rotilie.   

Abstract

Chemical and cellular characteristics of fluid within subcutaneously implanted polyethylene chambers in rabbits were studied over a 3-month period. The fluid attained a relatively stable protein and cellular composition which was consistent with a mononuclear exudate. After a single dose of intramuscular penicillin G, the antibacterial activity of chamber fluid was found to be dynamic and similar to the serum antibacterial activity. This animal model may be useful for in vivo studies of the interaction of microorganisms with antimicrobial agents.

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Year:  1975        PMID： 1190755      PMCID： PMC429380          DOI： 10.1128/AAC.8.4.495

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Cultivation of pathogenic Treponema pallidum in chambers surgically implanted in experimental animals.

Authors:  T Rathlev
Journal:  Acta Pathol Microbiol Scand B Microbiol Immunol       Date:  1973-04

2.  Implantation and use of a subcutaneous culture chamber in laboratory animals.

Authors:  R J Arko
Journal:  Lab Anim Sci       Date:  1973-02

3.  Fluid and pharmacological dynamics in a subcutaneous chamber implanted in rats.

Authors:  W G Gardner; R B Prior; R L Perkins
Journal:  Antimicrob Agents Chemother       Date:  1973-08       Impact factor: 5.191

4.  Concentration of antibacterial agents in interstitial tissue fluid.

Authors:  G D Chisholm; P M Waterworth; J S Calnan; L P Garrod
Journal:  Br Med J       Date:  1973-03-10

5.  [Experimental body cavities in rabbits for the analysis of possible bacterial virulence factors (author's transl)].

Authors:  E Frese; H Blobel
Journal:  Zentralbl Bakteriol Orig A       Date:  1974-12

6.  Neisseria gonorrhoeae: experimental infection of laboratory animals.

Authors:  R J Arko
Journal:  Science       Date:  1972-09-29       Impact factor: 47.728
  6 in total
  10 in total

1.  Use of recombinase-based in vivo expression technology to characterize Enterococcus faecalis gene expression during infection identifies in vivo-expressed antisense RNAs and implicates the protease Eep in pathogenesis.

Authors:  Kristi L Frank; Aaron M T Barnes; Suzanne M Grindle; Dawn A Manias; Patrick M Schlievert; Gary M Dunny
Journal:  Infect Immun       Date:  2011-12-05       Impact factor: 3.441

2.  Composition of fluids from diffusion chambers implanted in the soft tissue and kidneys of rabbits.

Authors:  F P Schmook; M Nefzger; G Laber; A Georgopoulos; R Czok; E Schütze
Journal:  Infection       Date:  1980       Impact factor: 3.553

3.  A diffusion chamber technique for measuring concentrations of antibiotics in interstitial fluid.

Authors:  G Laber; E Schütze; R Leskova; R Kolb; A Georgopoulos
Journal:  Infection       Date:  1980       Impact factor: 3.553

4.  Cephalosporin and aminoglycoside concentrations in peritoneal capsular fluid in rabbits.

Authors:  D N Gerding; W H Hall; E A Schierl; R E Manion
Journal:  Antimicrob Agents Chemother       Date:  1976-12       Impact factor: 5.191

5.  Ampicillin therapy of experimental enterococcal endocarditis.

Authors:  R R Tight
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

6.  Characterization of Staphylococcus aureus isolates from patients with toxic shock syndrome, using polyethylene infection chambers in rabbits.

Authors:  D F Scott; J M Kling; J J Kirkland; G K Best
Journal:  Infect Immun       Date:  1983-01       Impact factor: 3.441

7.  Treponema pallidum infection in subcutaneous polyethylene chambers in rabbits.

Authors:  R R Tight; R L Perkins
Journal:  Infect Immun       Date:  1976-06       Impact factor: 3.441

8.  Serum and subcutaneous chamber fluid dynamics of penicillins after single large parenteral doses.

Authors:  R R Tight; A C White
Journal:  Antimicrob Agents Chemother       Date:  1980-02       Impact factor: 5.191

9.  Penetration of cefazolin, cephaloridine, and cefamandole into interstitial fluid in rabbits.

Authors:  C Carbon; A Contrepois; N Brion; S Lamotte-Barrillon
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191

10.  Transcriptome analysis of Enterococcus faecalis during mammalian infection shows cells undergo adaptation and exist in a stringent response state.

Authors:  Kristi L Frank; Cristina Colomer-Winter; Suzanne M Grindle; José A Lemos; Patrick M Schlievert; Gary M Dunny
Journal:  PLoS One       Date:  2014-12-29       Impact factor: 3.240
  10 in total

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