Literature DB >> 11897605

Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria.

Paul N Newton1, Michele van Vugt, Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Maneerat Rasameesoroj, Pramote Teerapong, Ronatrai Ruangveerayuth, Thra Slight, Francois Nosten, Yupin Suputtamongkol, Sornchai Looareesuwan, Nicholas J White.   

Abstract

Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

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Year:  2002        PMID： 11897605      PMCID： PMC127101          DOI： 10.1128/AAC.46.4.1125-1127.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

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Journal:  Trop Med Int Health       Date:  1999-09       Impact factor: 2.622

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Authors:  Y Suputtamongkol; P N Newton; B Angus; P Teja-Isavadharm; D Keeratithakul; M Rasameesoraj; S Pukrittayakamee; N J White
Journal:  Br J Clin Pharmacol       Date:  2001-12       Impact factor: 4.335

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Authors:  A Brockman; R N Price; M van Vugt; D G Heppner; D Walsh; P Sookto; T Wimonwattrawatee; S Looareesuwan; N J White; F Nosten
Journal:  Trans R Soc Trop Med Hyg       Date:  2000 Sep-Oct       Impact factor: 2.184

7.  Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria.

Authors:  T Q Binh; K F Ilett; K T Batty; T M Davis; N C Hung; S M Powell; L T Thu; H V Thien; H L Phuöng; V D Phuong
Journal:  Br J Clin Pharmacol       Date:  2001-06       Impact factor: 4.335

8.  Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria.

Authors:  P Newton; Y Suputtamongkol; P Teja-Isavadharm; S Pukrittayakamee; V Navaratnam; I Bates; N White
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

9.  Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: use of simultaneous measurement by high performance liquid chromatography and bioassay.

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Journal:  Br J Clin Pharmacol       Date:  1996-11       Impact factor: 4.335

Review 10.  Artesunate. A review of its pharmacology and therapeutic efficacy in the treatment of malaria.

Authors:  L B Barradell; A Fitton
Journal:  Drugs       Date:  1995-10       Impact factor: 9.546
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Review 1.  Artemisinins.

Authors:  C J Woodrow; R K Haynes; S Krishna
Journal:  Postgrad Med J       Date:  2005-02       Impact factor: 2.401

2.  Comparative oral bioavailability of non-fixed and fixed combinations of artesunate and amodiaquine in healthy Indian male volunteers.

Authors:  Anny Fortin; Roger K Verbeeck; Frans H Jansen
Journal:  Eur J Clin Pharmacol       Date:  2010-10-15       Impact factor: 2.953

3.  Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria.

Authors:  Joel Tarning; Marcus J Rijken; Rose McGready; Aung Pyae Phyo; Warunee Hanpithakpong; Nicholas P J Day; Nicholas J White; François Nosten; Niklas Lindegardh
Journal:  Antimicrob Agents Chemother       Date:  2012-01-17       Impact factor: 5.191

4.  Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro.

Authors:  Sant Muangnoicharoen; David J Johnson; Sornchai Looareesuwan; Srivicha Krudsood; Stephen A Ward
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

5.  Application of mobile-technology for disease and treatment monitoring of malaria in the "Better Border Healthcare Programme".

Authors:  Pongthep Meankaew; Jaranit Kaewkungwal; Amnat Khamsiriwatchara; Podjadeach Khunthong; Pratap Singhasivanon; Wichai Satimai
Journal:  Malar J       Date:  2010-08-19       Impact factor: 2.979

6.  Artemether bioavailability after oral or intramuscular administration in uncomplicated falciparum malaria.

Authors:  Kamolrat Silamut; Paul N Newton; Paktiya Teja-Isavadharm; Yupin Suputtamongkol; Duangsuda Siriyanonda; Maneerat Rasameesoraj; Sasithon Pukrittayakamee; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

7.  A screening-based approach to circumvent tumor microenvironment-driven intrinsic resistance to BCR-ABL+ inhibitors in Ph+ acute lymphoblastic leukemia.

Authors:  Harpreet Singh; Anang A Shelat; Amandeep Singh; Nidal Boulos; Richard T Williams; R Kiplin Guy
Journal:  J Biomol Screen       Date:  2013-08-29

8.  Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia.

Authors:  Amit Budhraja; Meghan E Turnis; Michelle L Churchman; Anisha Kothari; Xue Yang; Haiyan Xu; Ewa Kaminska; John C Panetta; David Finkelstein; Charles G Mullighan; Joseph T Opferman
Journal:  Clin Cancer Res       Date:  2017-10-03       Impact factor: 12.531

9.  Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers.

Authors:  Visweswaran Navaratnam; Surash Ramanathan; Mohd Suhaimi Ab Wahab; Gan Siew Hua; Sharif Mahsufi Mansor; Jean-René Kiechel; Michel Vaillant; Walter R J Taylor; Piero Olliaro
Journal:  Eur J Clin Pharmacol       Date:  2009-04-30       Impact factor: 2.953

10.  Residual antimalarials in malaria patients from Tanzania--implications on drug efficacy assessment and spread of parasite resistance.

Authors:  Eva Maria Hodel; Abdunoor Mulokozi Kabanywanyi; Aggrey Malila; Boris Zanolari; Thomas Mercier; Hans-Peter Beck; Thierry Buclin; Piero Olliaro; Laurent Arthur Decosterd; Blaise Genton
Journal:  PLoS One       Date:  2009-12-14       Impact factor: 3.240
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