BACKGROUND: The role of lymph node dissection in the treatment of differentiated thyroid carcinoma remains controversial, and the benefit of therapy is debatable. This study was designed to identify the precise localization of lymph node micrometastases (LNMM) and map their cervical involvement in relation with the tumor location within the thyroid gland. METHODS: A total of 2551 cervical lymph nodes were obtained from 80 patients with well-differentiated thyroid cancer. They were diagnosed as clear lymph nodes by hematoxylin and eosin stain and then examined immunohistochemically with cytokeratins (AE1/AE3) for evidence of micrometastases. RESULTS: Forty-two patients out of 80 (53%) had LNMM. Forty-eight patients (60%) had the tumor confined to only one third of 1 of the 2 lobes of the thyroid gland or isthmus. The frequencies and locations of LNMM in patients were 50% (3/6) in the deep upper cervical nodes, with tumors localized in the upper third; 31% (5/16) in the paraglandular nodes, with tumors affecting the middle third; 63% (12/19) in the paratracheal nodes, with tumors affecting the lower third of the thyroid lobe; and 71% (5/7) in the pretracheal nodes in the isthmus-located tumor. All the LNMM occurred on the ipsilateral side of the tumor. CONCLUSIONS: When thyroid carcinoma is located in the upper third of the thyroid lobe, the LNMM are found in the direction of upward lymphatic flow. When the tumor is located in the lower third or isthmus, LNMM are directed downward. In addition, early thyroid carcinoma micrometastases do not cross the midline but remain on the ipsilateral side of the tumor.
BACKGROUND: The role of lymph node dissection in the treatment of differentiated thyroid carcinoma remains controversial, and the benefit of therapy is debatable. This study was designed to identify the precise localization of lymph node micrometastases (LNMM) and map their cervical involvement in relation with the tumor location within the thyroid gland. METHODS: A total of 2551 cervical lymph nodes were obtained from 80 patients with well-differentiated thyroid cancer. They were diagnosed as clear lymph nodes by hematoxylin and eosin stain and then examined immunohistochemically with cytokeratins (AE1/AE3) for evidence of micrometastases. RESULTS: Forty-two patients out of 80 (53%) had LNMM. Forty-eight patients (60%) had the tumor confined to only one third of 1 of the 2 lobes of the thyroid gland or isthmus. The frequencies and locations of LNMM in patients were 50% (3/6) in the deep upper cervical nodes, with tumors localized in the upper third; 31% (5/16) in the paraglandular nodes, with tumors affecting the middle third; 63% (12/19) in the paratracheal nodes, with tumors affecting the lower third of the thyroid lobe; and 71% (5/7) in the pretracheal nodes in the isthmus-located tumor. All the LNMM occurred on the ipsilateral side of the tumor. CONCLUSIONS: When thyroid carcinoma is located in the upper third of the thyroid lobe, the LNMM are found in the direction of upward lymphatic flow. When the tumor is located in the lower third or isthmus, LNMM are directed downward. In addition, early thyroid carcinoma micrometastases do not cross the midline but remain on the ipsilateral side of the tumor.
Authors: Soo Young Kim; Bup-Woo Kim; Ju Yeon Pyo; Soon Won Hong; Hang-Seok Chang; Cheong Soo Park Journal: World J Surg Date: 2018-01 Impact factor: 3.352
Authors: M Gershinsky; O Barnett-Griness; N Stein; D Hirsch; G Tzvetov; O Bardicef; J Pauker; S Grozinsky-Glasberg; S Ish-Shalom; I Slutski; I Shimon; C Benbassat Journal: J Endocrinol Invest Date: 2011-09-27 Impact factor: 4.256
Authors: R Gelmini; M Campanelli; F Cabry; A Franceschetto; G Ceresini; L Ruffini; A Zaccaroni; P Del Rio Journal: J Endocrinol Invest Date: 2017-08-31 Impact factor: 4.256
Authors: Henning Dralle; Thomas J Musholt; Jochen Schabram; Thomas Steinmüller; Andreja Frilling; Dietmar Simon; Peter E Goretzki; Bruno Niederle; Christian Scheuba; Thomas Clerici; Michael Hermann; Jochen Kußmann; Kerstin Lorenz; Christoph Nies; Peter Schabram; Arnold Trupka; Andreas Zielke; Wolfram Karges; Markus Luster; Kurt W Schmid; Dirk Vordermark; Hans-Joachim Schmoll; Reinhard Mühlenberg; Otmar Schober; Harald Rimmele; Andreas Machens Journal: Langenbecks Arch Surg Date: 2013-03-03 Impact factor: 3.445