Literature DB >> 11893329

Opioid tolerance-in search of the holy grail.

Brigitte L Kieffer1, Christopher J Evans.   

Abstract

Tolerance, one of several behavioral adaptations to prolonged opioid treatment, has long been explained by desensitization of opioid receptor signaling and loss of surface receptors. However, recent evidence presents an alternative hypothesis, suggesting that receptor internalization could in fact reduce tolerance in vivo.

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Year:  2002        PMID： 11893329     DOI： 10.1016/s0092-8674(02)00666-9

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  51 in total

Review 1.  Ligand-directed signalling within the opioid receptor family.

Authors:  Amynah A Pradhan; Monique L Smith; Brigitte L Kieffer; Christopher J Evans
Journal:  Br J Pharmacol       Date:  2012-11       Impact factor: 8.739

2.  Molecular basis of cellular localization of poly C binding protein 1 in neuronal cells.

Authors:  Andrea M Berry; Kelly E Flock; Horace H Loh; Jane L Ko
Journal:  Biochem Biophys Res Commun       Date:  2006-09-12       Impact factor: 3.575

3.  Opioids and efflux transporters. Part 1: P-glycoprotein substrate activity of N-substituted analogs of meperidine.

Authors:  Susan L Mercer; Hazem E Hassan; Christopher W Cunningham; Natalie D Eddington; Andrew Coop
Journal:  Bioorg Med Chem Lett       Date:  2006-12-21       Impact factor: 2.823

4.  Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state.

Authors:  Minoru Narita; Satoshi Imai; Atsushi Nakamura; Ayumi Ozeki; Megumi Asato; Mahardian Rahmadi; Yuka Sudo; Minoru Hojo; Yasuhito Uezono; Lakshmi A Devi; Naoko Kuzumaki; Tsutomu Suzuki
Journal:  Addict Biol       Date:  2011-08-04       Impact factor: 4.280

5.  Consensus 3D model of μ-opioid receptor ligand efficacy based on a quantitative Conformationally Sampled Pharmacophore.

Authors:  Jihyun Shim; Andrew Coop; Alexander D MacKerell
Journal:  J Phys Chem B       Date:  2011-05-12       Impact factor: 2.991

Review 6.  Opioid analgesics and P-glycoprotein efflux transporters: a potential systems-level contribution to analgesic tolerance.

Authors:  Susan L Mercer; Andrew Coop
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

7.  Effects of trichostatin A on neuronal mu-opioid receptor gene expression.

Authors:  Ying-Chih Lin; Kelly E Flock; Ryan J Cook; Amanda J Hunkele; Horace H Loh; Jane L Ko
Journal:  Brain Res       Date:  2008-10-11       Impact factor: 3.252

8.  Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity.

Authors:  Jianren Mao; Backil Sung; Ru-Rong Ji; Grewo Lim
Journal:  J Neurosci       Date:  2002-09-15       Impact factor: 6.167

9.  G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.

Authors:  Gregory W Terman; Wenzhen Jin; Young-Pyo Cheong; Janet Lowe; Marc G Caron; Robert J Lefkowitz; Charles Chavkin
Journal:  Br J Pharmacol       Date:  2003-12-08       Impact factor: 8.739

10.  Morphine and fentanyl differently affect MOP and NOP gene expression in human neuroblastoma SH-SY5Y cells.

Authors:  Francesca Felicia Caputi; Francesca Lattanzio; Donatella Carretta; Daniela Mercatelli; Sanzio Candeletti; Patrizia Romualdi
Journal:  J Mol Neurosci       Date:  2013-05-29       Impact factor: 3.444
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