Literature DB >> 11882006

Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes.

Yoshiaki Hamada1, Hidekazu Tokuhara, Araki Masuyama, Masatomo Nojima, Hye-Sook Kim, Kanako Ono, Naoki Ogura, Yusuke Wataya.   

Abstract

Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).

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Year:  2002        PMID： 11882006     DOI： 10.1021/jm010473w

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Generation of singlet oxygen from fragmentation of monoactivated 1,1-dihydroperoxides.

Authors:  Jiliang Hang; Prasanta Ghorai; Solaire A Finkenstaedt-Quinn; Ilhan Findik; Emily Sliz; Keith T Kuwata; Patrick H Dussault
Journal:  J Org Chem       Date:  2012-01-23       Impact factor: 4.354

2.  Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.

Authors:  Steven W M Crossley; Carla Obradors; Ruben M Martinez; Ryan A Shenvi
Journal:  Chem Rev       Date:  2016-07-27       Impact factor: 60.622

3.  Synthesis of alkyl hydroperoxides via alkylation of gem-dihydroperoxides.

Authors:  ShivaKumar Kyasa; Benjamin W Puffer; Patrick H Dussault
Journal:  J Org Chem       Date:  2013-03-18       Impact factor: 4.354

4.  Mild and efficient strontium chloride hexahydrate-catalyzed conversion of ketones and aldehydes into corresponding gem-dihydroperoxides by aqueous H2O2.

Authors:  Davood Azarifar; Kaveh Khosravi; Fatemeh Soleimanei
Journal:  Molecules       Date:  2010-03-08       Impact factor: 4.411

5.  A click-based modular approach to introduction of peroxides onto molecules and nanostructures.

Authors:  Alissa Horn; Patrick H Dussault
Journal:  RSC Adv       Date:  2020-12-16       Impact factor: 4.036
  5 in total

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