| Literature DB >> 11881728 |
K Sakurai1, M Urade, K Noguchi, H Kishimoto, M Ishibashi, H Yasoshima, T Yamamoto, A Kubota.
Abstract
We examined the immunohistochemical localization of cyclooxygenase (COX)-2 in human salivary gland tumors. Thirty salivary gland adenomas (SGA), 40 salivary gland carcinomas (SGC) and 15 normal salivary glands (NSG) were studied. NSG showed restricted COX-2 staining only in the epithelial cells of salivary ducts. In contrast, COX-2 protein was detected in 27 cases of SGA (90%), except for three myoepitheliomas, and in all cases of SGC (100%) at various intensities and in various fashions. Thirteen SGA (43%) and 36 SGC (90%) cases showed strong COX-2 staining predominantly in tumor cells containing ductal components, as did serous and mucous acinic components of acinic cell carcinomas, mucoepidermoid carcinomas and mucinous carcinomas. These findings may suggest that COX-2 in salivary gland tumors is expressed in tumor cells derived from pluripotential ductal epithelium that can histologically develop into either serous or mucinous acinar cells.Entities:
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Year: 2001 PMID： 11881728 DOI： 10.1046/j.1440-1827.2001.01280.x
Source DB: PubMed Journal: Pathol Int ISSN： 1320-5463 Impact factor: 2.534