Literature DB >> 1187344

Reaction of a nucleoside 2, 4-dinitrophenyl phosphate with fluoride; a convenient method for the preparation of the nucleoside phosphorfluoridate.

P W Johnson, R von Tigerstrom, M Smith.   

Abstract

Examination of the reaction of 2, 4-dinitrofluorobenzene with thymidine-5' phosphate in detail reveals that the initial product is the 2, 4-dinitrophenyl ester. This reacts with fluoride to produce thymidine-5' phosphorfluoridate. This second reaction provides the basis for the conversion of preformed thymidine-5' 2, 4-dinitrophenyl phosphate to thymidine-5' phosphorofluoridate.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1187344      PMCID： PMC343542          DOI： 10.1093/nar/2.10.1745

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  5 in total

1.  Macromolecular enzymatic product of NAD+ in liver mitochondria.

Authors:  E Kun; P H Zimber; A C Chang; B Puschendorf; H Grunicke
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

2.  Preparation of the 2,4-dinitrophenyl esters of thymidine 3'-and thymidine 5'-phosphate and their use as substrates fof phosphodiesterases.

Authors:  R G von Tigerstrom; M Smith
Journal:  Biochemistry       Date:  1969-07       Impact factor: 3.162

3.  Irreversible inhibition of nuclear exoribonuclease by thymidine-3'-fluorophosphate and p-haloacetamidophenyl nucleotides.

Authors:  M B Sporn; D M Berkowitz; R P Glinski; A Ash; C L Stevens
Journal:  Science       Date:  1969-06-20       Impact factor: 47.728

4.  Oligodeoxyribonucleotides: chemical synthesis in anhydrous base.

Authors:  R Von Tigerstrom; M Smith
Journal:  Science       Date:  1970-02-27       Impact factor: 47.728

5.  Nucleotide synthesis. II. Nucleotide p-nitrophenyl and 2,4-dinitrophenyl esters.

Authors:  R K Borden; M Smith
Journal:  J Org Chem       Date:  1966-10       Impact factor: 4.354
  5 in total
  1 in total

1.  The mechanism of the chemical synthesis of oligonucleotides and its synthetic consequences.

Authors:  D G Knorre; V F Zarytova
Journal:  Nucleic Acids Res       Date:  1976-10       Impact factor: 16.971
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.