Literature DB >> 5411914

Oligodeoxyribonucleotides: chemical synthesis in anhydrous base.

R Von Tigerstrom, M Smith.   

Abstract

The sugar hydroxyl of a methoxytrityldeoxyribonucleoside reacts with a methoxytrityldeoxyribonucleoside phosphorofluoridate in dimethylformamide and potassium tertiary butoxide to yield the protected dinucleoside monophosphate. The reaction is fast and specific, and is used in a stepwise synthesis to prepare trinucleoside diphosphate and tetranucleoside triphosphate.

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Year:  1970        PMID： 5411914     DOI： 10.1126/science.167.3922.1266

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  3 in total

1.  The synthesis of the internucleotide (phosphodiester) bond by a base-catalysed reaction.

Authors:  R von Tigerstrom; P Jahnke; M Smith
Journal:  Nucleic Acids Res       Date:  1975-10       Impact factor: 16.971

2.  Reaction of a nucleoside 2, 4-dinitrophenyl phosphate with fluoride; a convenient method for the preparation of the nucleoside phosphorfluoridate.

Authors:  P W Johnson; R von Tigerstrom; M Smith
Journal:  Nucleic Acids Res       Date:  1975-10       Impact factor: 16.971

3.  Application of base-catalysed reaction to the synthesis of dinucleotides containing the four common deoxyribonucleosides and of oligodeoxythymidylates.

Authors:  R von Tigerstrom; P Jahnke; V Wylie; M Smith
Journal:  Nucleic Acids Res       Date:  1975-10       Impact factor: 16.971
  3 in total

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