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Literature DB >> 11871657

Human ribonuclease P: subunits, function, and intranuclear localization.

Abstract

Catalytic complexes of nuclear ribonuclease P (RNase P) ribonucleoproteins are composed of several protein subunits that appear to have specific roles in enzyme function in tRNA processing. This review describes recent progress made in the characterization of human RNase P, its relationship with the ribosomal RNA processing ribonucleoprotein RNase MRP, and the unexpected evolutionary conservation of its subunits. A new model for the biosynthesis of human RNase P is presented, in which this process is dynamic, transcription-dependent, and implicates functionally distinct nuclear compartments in tRNA biogenesis.

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Year: 2002 PMID： 11871657 PMCID： PMC1370226 DOI： 10.1017/s1355838202011184

Source DB: PubMed Journal: RNA ISSN： 1355-8382 Impact factor: 4.942

80 in total

1. Molecular modeling of the three-dimensional architecture of the RNA component of yeast RNase MRP.

Authors: M E Schmitt
Journal: J Mol Biol Date: 1999-10-01 Impact factor: 5.469

2. High mobility of proteins in the mammalian cell nucleus.

Authors: R D Phair; T Misteli
Journal: Nature Date: 2000-04-06 Impact factor: 49.962

3. Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.

Authors: H Qiu; C Hu; J Anderson; G R Björk; S Sarkar; A K Hopper; A G Hinnebusch
Journal: Mol Cell Biol Date: 2000-04 Impact factor: 4.272

Review 4. Like attracts like: getting RNA processing together in the nucleus.

Authors: J D Lewis; D Tollervey
Journal: Science Date: 2000-05-26 Impact factor: 47.728

Review 5. Review: perinucleolar structures.

Authors: S Huang
Journal: J Struct Biol Date: 2000-04 Impact factor: 2.867

6. Protein components contribute to active site architecture for eukaryotic ribonuclease P.

Authors: H L True; D W Celander
Journal: J Biol Chem Date: 1998-03-27 Impact factor: 5.157

7. Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation.

Authors: T Cai; T R Reilly; M Cerio; M E Schmitt
Journal: Mol Cell Biol Date: 1999-11 Impact factor: 4.272

8. Proteasome mutants, pre4-2 and ump1-2, suppress the essential function but not the mitochondrial RNase P function of the Saccharomyces cerevisiae gene RPM2.

Authors: M S Lutz; S R Ellis; N C Martin
Journal: Genetics Date: 2000-03 Impact factor: 4.562

Review 9. The nucleolus and the four ribonucleoproteins of translation.

Authors: T Pederson; J C Politz
Journal: J Cell Biol Date: 2000-03-20 Impact factor: 10.539

10. Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P.

Authors: N Jarrous; J S Wolenski; D Wesolowski; C Lee; S Altman
Journal: J Cell Biol Date: 1999-08-09 Impact factor: 10.539

39 in total

1. Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P.

Authors: William P Boomershine; Craig A McElroy; Hsin-Yue Tsai; Ross C Wilson; Venkat Gopalan; Mark P Foster
Journal: Proc Natl Acad Sci U S A Date: 2003-12-12 Impact factor: 11.205

2. Alterations in the intracellular level of a protein subunit of human RNase P affect processing of tRNA precursors.

Authors: Amit Cohen; Robert Reiner; Nayef Jarrous
Journal: Nucleic Acids Res Date: 2003-08-15 Impact factor: 16.971

3. Partial reconstitution of human RNase P in HeLa cells between its RNA subunit with an affinity tag and the intact protein components.

Authors: Yong Li; Sidney Altman
Journal: Nucleic Acids Res Date: 2002-09-01 Impact factor: 16.971

Human ribonuclease P: subunits, function, and intranuclear localization.

1. Molecular modeling of the three-dimensional architecture of the RNA component of yeast RNase MRP.

2. High mobility of proteins in the mammalian cell nucleus.

3. Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.

Review 4. Like attracts like: getting RNA processing together in the nucleus.

Review 5. Review: perinucleolar structures.

6. Protein components contribute to active site architecture for eukaryotic ribonuclease P.

7. Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation.

8. Proteasome mutants, pre4-2 and ump1-2, suppress the essential function but not the mitochondrial RNase P function of the Saccharomyces cerevisiae gene RPM2.

Review 9. The nucleolus and the four ribonucleoproteins of translation.

10. Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P.

1. Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P.

2. Alterations in the intracellular level of a protein subunit of human RNase P affect processing of tRNA precursors.

3. Partial reconstitution of human RNase P in HeLa cells between its RNA subunit with an affinity tag and the intact protein components.

4. Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.

Review 5. Of proteins and RNA: the RNase P/MRP family.

6. 3D models of yeast RNase P/MRP proteins Rpp1p and Pop3p.

7. A role for the catalytic ribonucleoprotein RNase P in RNA polymerase III transcription.

8. Ribonuclease P: the evolution of an ancient RNA enzyme.

9. Heterodimerization regulates RNase MRP/RNase P association, localization, and expression of Rpp20 and Rpp25.

10. Structure and function of eukaryotic Ribonuclease P RNA.