Literature DB >> 11869098

Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis.

Melissa M Wagenaar1, Donna M Gibson, Jon Clardy.   

Abstract

[structure: see text] Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH2Cl2 extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Akanthomycin was characterized using X-ray crystallography and NMR.

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Year:  2002        PMID： 11869098     DOI： 10.1021/ol016737q

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

1.  Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum.

Authors:  Mallika Kumarihamy; Shabana I Khan; Melissa Jacob; Babu L Tekwani; Stephen O Duke; Daneel Ferreira; N P Dhammika Nanayakkara
Journal:  J Nat Prod       Date:  2012-04-24       Impact factor: 4.050

2.  Cultivation of entomopathogenic fungi for the search of antibacterial compounds.

Authors:  Si-Young Lee; Ikuo Nakajima; Fumio Ihara; Hiroshi Kinoshita; Takuya Nihira
Journal:  Mycopathologia       Date:  2005-11       Impact factor: 2.574

3.  Computational Prediction and Experimental Validation of a Bridged Cation Intermediate in Akanthomycin Biosynthesis.

Authors:  Cooper S Jamieson; Masao Ohashi; K N Houk; Yi Tang
Journal:  J Am Chem Soc       Date:  2022-03-17       Impact factor: 16.383

4.  Akanthopyrones A-D, α-Pyrones Bearing a 4-O-Methyl-β-d-glucopyranose Moiety from the Spider-Associated Ascomycete Akanthomyces novoguineensis.

Authors:  Wilawan Kuephadungphan; Soleiman E Helaly; Charuwan Daengrot; Souwalak Phongpaichit; Janet Jennifer Luangsa-Ard; Vatcharin Rukachaisirikul; Marc Stadler
Journal:  Molecules       Date:  2017-07-18       Impact factor: 4.411

5.  2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease.

Authors:  Katrina L Forrestall; Darcy E Burley; Meghan K Cash; Ian R Pottie; Sultan Darvesh
Journal:  Chem Biol Interact       Date:  2020-12-02       Impact factor: 5.192

Review 6.  Microbial Natural Products with Antiviral Activities, Including Anti-SARS-CoV-2: A Review.

Authors:  Andri Frediansyah; Fajar Sofyantoro; Saad Alhumaid; Abbas Al Mutair; Hawra Albayat; Hayyan I Altaweil; Hani M Al-Afghani; Abdullah A AlRamadhan; Mariam R AlGhazal; Safaa A Turkistani; Abdulmonem A Abuzaid; Ali A Rabaan
Journal:  Molecules       Date:  2022-07-05       Impact factor: 4.927

7.  Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy.

Authors:  Tuoping Luo; Stuart L Schreiber
Journal:  J Am Chem Soc       Date:  2009-04-22       Impact factor: 15.419

Review 8.  The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management.

Authors:  Alexander Berestetskiy; Qiongbo Hu
Journal:  Microorganisms       Date:  2021-06-24
  8 in total

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