Literature DB >> 11866586

SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating.

Paul H Schlesinger1, Riccardo Ferdani, Jun Liu, Jolanta Pajewska, Robert Pajewski, Mitsuyoshi Saito, Hossein Shabany, George W Gokel.   

Abstract

The design, synthesis, and characterization of a synthetic chloride membrane transporter, SCMTR (synthetic chloride membrane transporter, "scimitar"), are presented. The compound [CH3(CH2)17]2NCOCH2OCH2CO-GGGPGGG-OBzl inserts rapidly into liposomes and planar lipid bilayers. SCMTR has a 1.3 +/- 0.01 nS chloride diffusion pathway (>10:1 Cl/K selectivity). Evidence was also obtained for voltage gating behavior.

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Year:  2002        PMID： 11866586     DOI： 10.1021/ja016784d

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  23 in total

1.  Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells.

Authors:  W Matthew Leevy; Seth T Gammon; Tatiana Levchenko; David D Daranciang; Oscar Murillo; Vladimir Torchilin; David Piwnica-Worms; James E Huettner; George W Gokel
Journal:  Org Biomol Chem       Date:  2005-08-26       Impact factor: 3.876

2.  Activity of synthetic ion channels is influenced by cation-pi interactions with phospholipid headgroups.

Authors:  Michelle E Weber; Elizabeth K Elliott; George W Gokel
Journal:  Org Biomol Chem       Date:  2005-11-30       Impact factor: 3.876

3.  A synthetic, chloride-selective channel that alters chloride transport in epithelial cells.

Authors:  Robert Pajewski; Raquel Garcia-Medina; Steven L Brody; W Matthew Leevy; Paul H Schlesinger; George W Gokel
Journal:  Chem Commun (Camb)       Date:  2005-11-22       Impact factor: 6.222

Review 4.  Development of synthetic membrane transporters for anions.

Authors:  Anthony P Davis; David N Sheppard; Bradley D Smith
Journal:  Chem Soc Rev       Date:  2006-10-23       Impact factor: 54.564

5.  Fluorescent, synthetic amphiphilic heptapeptide anion transporters: evidence for self-assembly and membrane localization in liposomes.

Authors:  Lei You; George W Gokel
Journal:  Chemistry       Date:  2008       Impact factor: 5.236

6.  Planar bilayer studies reveal multiple conductance states for synthetic anion transporters.

Authors:  Riccardo Ferdani; George W Gokel
Journal:  Org Biomol Chem       Date:  2006-08-29       Impact factor: 3.876

7.  Carboxylate anion diminishes chloride transport through a synthetic, self-assembled transmembrane pore.

Authors:  Lei You; Riccardo Ferdani; Ruiqiong Li; Joseph P Kramer; Rudolph Ernst K Winter; George W Gokel
Journal:  Chemistry       Date:  2008       Impact factor: 5.236

8.  Anion transport properties of amine and amide-sidechained peptides are affected by charge and phospholipid composition.

Authors:  Lei You; Ruiqiong Li; George W Gokel
Journal:  Org Biomol Chem       Date:  2008-06-16       Impact factor: 3.876

9.  The C- and N-Terminal Residues of Synthetic Heptapeptide Ion Channels Influence Transport Efficacy Through Phospholipid Bilayers.

Authors:  Natasha Djedovič; Riccardo Ferdani; Egan Harder; Jolanta Pajewska; Robert Pajewski; Michelle E Weber; Paul H Schlesinger; George W Gokel
Journal:  New J Chem       Date:  2005-01-01       Impact factor: 3.591

10.  Aggregation behavior and dynamics of synthetic amphiphiles that self-assemble to anion transporters.

Authors:  Elizabeth K Elliott; Megan M Daschbach; George W Gokel
Journal:  Chemistry       Date:  2008       Impact factor: 5.236
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