| Literature DB >> 11140722 |
J W Tilley1, G Kaplan, K Rowan, V Schwinge, B Wolitzky.
Abstract
A series of imides and lactams derived from 4-amino-N-benzylpyroglutamyl-L-phenylalanine was prepared and evaluated for activity as VCAM/VLA-4 antagonists. Imides were more potent than the corresponding lactams; several had subnanomolar IC50s in an ELISA based assay and were also highly effective at blocking VLA-4 expressing Ramos cell binding to VCAM coated plates.Entities:
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Year: 2001 PMID： 11140722 DOI： 10.1016/s0960-894x(00)00582-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823