Literature DB >> 11864960

The ACT-1 plasmid-encoded AmpC beta-lactamase is inducible: detection in a complex beta-lactamase background.

Mark D Reisbig1, Nancy D Hanson.   

Abstract

The purpose of this study was to identify the genetic organization and inducibility of bla(ACT-1) in a clinical isolate of Klebsiella pneumoniae possessing at least five different beta-lactamases. The genetic organization of the bla(ACT-1)/ampR region is identical to those of inducible chromosomal ampC genes. RNA analysis using primer extension demonstrated a five-fold increase in bla(ACT-1) transcript production on exposure to cefoxitin. These findings are significant because induction was detected in a complicated beta-lactamase background. In addition, this report is the first to describe an inducible plasmid-encoded AmpC beta-lactamase of Enterobacter cloacae origin.

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Year:  2002        PMID： 11864960     DOI： 10.1093/jac/49.3.557

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  18 in total

1.  Occurrence of newer beta-lactamases in Klebsiella pneumoniae isolates from 24 U.S. hospitals.

Authors:  Ellen Smith Moland; Jennifer A Black; Jason Ourada; Mark D Reisbig; Nancy D Hanson; Kenneth S Thomson
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

2.  CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid.

Authors:  V Miriagou; L S Tzouvelekis; L Villa; E Lebessi; A C Vatopoulos; A Carattoli; E Tzelepi
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

3.  Model system to evaluate the effect of ampD mutations on AmpC-mediated beta-lactam resistance.

Authors:  Amber J Schmidtke; Nancy D Hanson
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

4.  Emergence of DHA-1-producing Klebsiella spp. in the Parisian region: genetic organization of the ampC and ampR genes originating from Morganella morganii.

Authors:  Charlotte Verdet; Yahia Benzerara; Valérie Gautier; Olivier Adam; Zahia Ould-Hocine; Guillaume Arlet
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

5.  Gene mutations responsible for overexpression of AmpC beta-lactamase in some clinical isolates of Enterobacter cloacae.

Authors:  Kenichi Kaneko; Ryoichi Okamoto; Ryuichi Nakano; Sayoko Kawakami; Matsuhisa Inoue
Journal:  J Clin Microbiol       Date:  2005-06       Impact factor: 5.948

6.  Expression of OXA-type and SFO-1 β-lactamases induces changes in peptidoglycan composition and affects bacterial fitness.

Authors:  Ana Fernández; Astrid Pérez; Juan A Ayala; Susana Mallo; Soraya Rumbo-Feal; Maria Tomás; Margarita Poza; Germán Bou
Journal:  Antimicrob Agents Chemother       Date:  2012-01-30       Impact factor: 5.191

7.  Promoter sequences necessary for high-level expression of the plasmid-associated ampC beta-lactamase gene blaMIR-1.

Authors:  Mark D Reisbig; Nancy D Hanson
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

8.  Occurrence of extended-spectrum and AmpC beta-lactamases in bloodstream isolates of Klebsiella pneumoniae: isolates harbor plasmid-mediated FOX-5 and ACT-1 AmpC beta-lactamases.

Authors:  Philip E Coudron; Nancy D Hanson; Michael W Climo
Journal:  J Clin Microbiol       Date:  2003-02       Impact factor: 5.948

Review 9.  AmpC beta-lactamases.

Authors:  George A Jacoby
Journal:  Clin Microbiol Rev       Date:  2009-01       Impact factor: 26.132

10.  Epidemiology of conjugative plasmid-mediated AmpC beta-lactamases in the United States.

Authors:  M Alvarez; J H Tran; N Chow; G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191
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