OBJECTIVE: To analyze invasive Candida infections in pediatric patients and to examine the outcome of disease. METHODS: An observational prospective study was carried out of microbiologically documented cases of invasive candidosis in neonates, infants and children at Hippokration Hospital from December 1993 to July 1995. RESULTS: Thirty-nine cases of invasive candidosis (mainly candidemia and candiduria) occurred in 38 patients aged 3 days to 14 years, 21 (54%) having occurred in patients aged <1 month. The incidence was 10.1/1000 admissions in the two neonatal departments versus 1.1/1000 for all other pediatric departments, including oncology (p<0.01). The most frequent causes of hospitalization were premature birth or perinatal problems and surgery. Thirty-five strains of Candida albicans, 10 of C. parapsilosis and eight of other or unidentified species were isolated. Non-C. albicans isolates, especially C. parapsilosis and C. glabrata, exhibited higher minimal inhibitory concentrations of azoles as compared with C. albicans. Thirteen patients (34%), all candidemic, died within 0--40 days. Untreated patients more frequently had positive cultures up to time of death (p<0.0001) and died (p=0.0006). CONCLUSIONS: Invasive candidosis is frequent in pediatric patients, especially premature neonates, and is associated with increased mortality. With early diagnosis and initiation of therapy the outcome is favorable.
OBJECTIVE: To analyze invasive Candida infections in pediatric patients and to examine the outcome of disease. METHODS: An observational prospective study was carried out of microbiologically documented cases of invasive candidosis in neonates, infants and children at Hippokration Hospital from December 1993 to July 1995. RESULTS: Thirty-nine cases of invasive candidosis (mainly candidemia and candiduria) occurred in 38 patients aged 3 days to 14 years, 21 (54%) having occurred in patients aged <1 month. The incidence was 10.1/1000 admissions in the two neonatal departments versus 1.1/1000 for all other pediatric departments, including oncology (p<0.01). The most frequent causes of hospitalization were premature birth or perinatal problems and surgery. Thirty-five strains of Candida albicans, 10 of C. parapsilosis and eight of other or unidentified species were isolated. Non-C. albicans isolates, especially C. parapsilosis and C. glabrata, exhibited higher minimal inhibitory concentrations of azoles as compared with C. albicans. Thirteen patients (34%), all candidemic, died within 0--40 days. Untreated patients more frequently had positive cultures up to time of death (p<0.0001) and died (p=0.0006). CONCLUSIONS:Invasive candidosis is frequent in pediatric patients, especially premature neonates, and is associated with increased mortality. With early diagnosis and initiation of therapy the outcome is favorable.
Authors: E Roilides; E Farmaki; J Evdoridou; J Dotis; E Hatziioannidis; M Tsivitanidou; E Bibashi; I Filioti; D Sofianou; C Gil-Lamaignere; F-M Mueller; G Kremenopoulos Journal: Eur J Clin Microbiol Infect Dis Date: 2004-10 Impact factor: 3.267
Authors: A L Colombo; J Perfect; M DiNubile; K Bartizal; M Motyl; P Hicks; R Lupinacci; C Sable; N Kartsonis Journal: Eur J Clin Microbiol Infect Dis Date: 2003-07-23 Impact factor: 3.267