Literature DB >> 11861902

Chemical incorporation of 1-methyladenosine into oligonucleotides.

Sergey N Mikhailov1, Jef Rozenski, Ekaterina V Efimtseva, Roger Busson, Arthur Van Aerschot, Piet Herdewijn.   

Abstract

The base moiety of 1-N-methyladenosine can be protected with a chloroacetyl group for incorporation of this modified nucleoside into DNA and RNA. Carefully controlled anhydrous conditions are needed for deprotection of the oligonucleotides.

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Year:  2002        PMID： 11861902      PMCID： PMC101250          DOI： 10.1093/nar/30.5.1124

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  16 in total

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