Literature DB >> 11860180

Diazoxide and pinacidil uncouple pyruvate-malate-induced mitochondrial respiration.

Dalia M Kopustinskiene1, Jovita Jovaisiene, Julius Liobikas, Adolfas Toleikis.   

Abstract

We investigated the effects of K(ATP) channel openers diazoxide and pinacidil on the respiration rate and membrane potential (deltapsi) of rat heart mitochondria, oxidizing pyruvate and malate. Diazoxide and pinacidil (58.8-1348.3 microM) increased the V2 (-ADP) respiration rate accordingly by 13-208% and 30-273% and decreased the deltapsi by 2-17% and 6-55%. These effects were also similar in the respiration medium without K+. Moreover, carboxyatractyloside completely abolished diazoxide- and pinacidil-induced uncoupling, indicating a role for the mitochondrial adenine nucleotide translocase in this process.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11860180     DOI： 10.1023/a:1013870704002

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  24 in total

1.  Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria.

Authors:  A J Kowaltowski; S Seetharaman; P Paucek; K D Garlid
Journal:  Am J Physiol Heart Circ Physiol       Date:  2001-02       Impact factor: 4.733

2.  Mitochondrial K(ATP) channels: probing molecular identity and pharmacology.

Authors:  A Terzic; P P Dzeja; E L Holmuhamedov
Journal:  J Mol Cell Cardiol       Date:  2000-11       Impact factor: 5.000

Review 3.  Mitochondria: a new target for K channel openers?

Authors:  A Szewczyk; E Marbán
Journal:  Trends Pharmacol Sci       Date:  1999-04       Impact factor: 14.819

4.  Determination of serum proteins by means of the biuret reaction.

Authors:  A G GORNALL; C J BARDAWILL; M M DAVID
Journal:  J Biol Chem       Date:  1949-02       Impact factor: 5.157

5.  Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties.

Authors:  R K Emaus; R Grunwald; J J Lemasters
Journal:  Biochim Biophys Acta       Date:  1986-07-23

6.  The role of mitochondrial potassium fluxes in controlling the protonmotive force in energized mitochondria.

Authors:  A Czyz; A Szewczyk; M J Nałecz; L Wojtczak
Journal:  Biochem Biophys Res Commun       Date:  1995-05-05       Impact factor: 3.575

7.  Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection.

Authors:  K D Garlid; P Paucek; V Yarov-Yarovoy; H N Murray; R B Darbenzio; A J D'Alonzo; N J Lodge; M A Smith; G J Grover
Journal:  Circ Res       Date:  1997-12       Impact factor: 17.367

Review 8.  ATP-Sensitive potassium channels: a review of their cardioprotective pharmacology.

Authors:  G J Grover; K D Garlid
Journal:  J Mol Cell Cardiol       Date:  2000-04       Impact factor: 5.000

9.  Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria.

Authors:  T Grimmsmann; I Rustenbeck
Journal:  Br J Pharmacol       Date:  1998-03       Impact factor: 8.739

10.  Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial function.

Authors:  E L Holmuhamedov; S Jovanović; P P Dzeja; A Jovanović; A Terzic
Journal:  Am J Physiol       Date:  1998-11
View more
  11 in total

1.  Effects of Ginkgo biloba extract on heart and liver mitochondrial functions: mechanism(s) of action.

Authors:  Giedre Baliutyte; Rasa Baniene; Sonata Trumbeckaite; Vilmante Borutaite; Adolfas Toleikis
Journal:  J Bioenerg Biomembr       Date:  2010-03-19       Impact factor: 2.945

2.  Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria.

Authors:  Tatiana Brustovetsky; Natalia Shalbuyeva; Nickolay Brustovetsky
Journal:  J Physiol       Date:  2005-07-28       Impact factor: 5.182

3.  Study of the mechanism of action of diazoxide on rat heart mitochondria under calcium loading.

Authors:  S M Korotkov; V P Nesterov; N N Ryabchikov
Journal:  Dokl Biochem Biophys       Date:  2006 May-Jun       Impact factor: 0.788

4.  Involvement of SH-groups during interaction of diazoxide with the inner membrane of rat heart mitochondria.

Authors:  S M Korotkov; V P Nesterov; L V Emel'yanova; N N Ryabchikov
Journal:  Dokl Biochem Biophys       Date:  2007 Jul-Aug       Impact factor: 0.788

5.  Effects of pinacidil and calcium on isolated rat heart mitochondria.

Authors:  S M Korotkov; L V Emel'yanova; I V Brailovskaya; V P Nesterov
Journal:  Dokl Biochem Biophys       Date:  2012-05-05       Impact factor: 0.788

6.  KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions.

Authors:  Matthias L Riess; Amadou K S Camara; André Heinen; Janis T Eells; Michele M Henry; David F Stowe
Journal:  J Cardiovasc Pharmacol       Date:  2008-05       Impact factor: 3.105

7.  Closure of mitochondrial potassium channels favors opening of the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria.

Authors:  Sergey M Korotkov; Irina V Brailovskaya; Anton R Shumakov; Larisa V Emelyanova
Journal:  J Bioenerg Biomembr       Date:  2015-04-14       Impact factor: 2.945

8.  Adenine nucleotide translocase mediates the K(ATP)-channel-openers-induced proton and potassium flux to the mitochondrial matrix.

Authors:  Dalia M Kopustinskiene; Adolfas Toleikis; Nils-Erik L Saris
Journal:  J Bioenerg Biomembr       Date:  2003-04       Impact factor: 2.945

9.  Opening of the mitoKATP channel and decoupling of mitochondrial complex II and III contribute to the suppression of myocardial reperfusion hyperoxygenation.

Authors:  Bin Liu; Xuehai Zhu; Chwen-Lih Chen; Keli Hu; Harold M Swartz; Yeong-Renn Chen; Guanglong He
Journal:  Mol Cell Biochem       Date:  2009-10-23       Impact factor: 3.396

Review 10.  The role of mitochondria in protection of the heart by preconditioning.

Authors:  Andrew P Halestrap; Samantha J Clarke; Igor Khaliulin
Journal:  Biochim Biophys Acta       Date:  2007-06-02
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.