| Literature DB >> 11855995 |
Adriana Chilin1, Christine Marzano, Adriano Guiotto, Francarosa Baccichetti, Francesco Carlassare, Franco Bordin.
Abstract
A new furoquinolinone derivative, namely 4-hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one (HOFQ), was synthesized and its biological activity studied. By UVA activation, HOFQ induced strong antiproliferative effects in Ehrlich ascite cells, which lost their ability to transmit the tumor by transplantation. HOFQ exhibited poor genotoxicity and absence of skin phototoxicity. Actually, HOFQ sensitization forms DNA-protein cross-linkages but not interstrands cross-links. Therefore, HOFQ appears to be a new promising drug for PUVA photochemotherapy and photopheresis.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11855995 DOI： 10.1021/jm010993r
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446