Literature DB >> 11855987

Synthesis and biolocalization of water-soluble sapphyrins.

Vladimir Král1, Julian Davis, Andrei Andrievsky, Jarmila Kralová, Alla Synytsya, Pavla Poucková, Jonathan L Sessler.   

Abstract

The synthesis, characterization, and biolocalization properties of new, fully water-soluble sapphyrins is reported. These systems, which display light absorbing features that make them of potential interest as photodynamic therapy (PDT) sensitizers, were found to localize selectively in pancreatic carcinoma tissue in a xenographic murine model. In this model, the concentration ratios for malignant tissue to surrounding muscle tissue were found to be as high as 280 in the most favorable case. The concentrations of the water-soluble sapphyrins reported here, as well as a porphyrin control system, were determined as a function of time and tissue type.

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Year:  2002        PMID： 11855987     DOI： 10.1021/jm0104320

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Functionalized 2,2'-Bipyrroles: Building Blocks for Pyrrolic Macrocycles.

Authors:  Gonzalo Anguera; James T Brewster; David Sánchez-García; Jonathan L Sessler
Journal:  Macroheterocycles       Date:  2018       Impact factor: 1.200

2.  Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization.

Authors:  Ana P Castano; Tatiana N Demidova; Michael R Hamblin
Journal:  Photodiagnosis Photodyn Ther       Date:  2004-12       Impact factor: 3.631

3.  Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility.

Authors:  K Eszter Borbas; Pawel Mroz; Michael R Hamblin; Jonathan S Lindsey
Journal:  Bioconjug Chem       Date:  2006 May-Jun       Impact factor: 4.774

4.  The effect of 5-aminolevulinic acid and its derivatives on protoporphyrin IX accumulation and apoptotic cell death in castrate-resistant prostate cancer cells.

Authors:  Ervin Teper; Peter Makhov; Konstantin Golovine; Daniel J Canter; Cynthia B Myers; Alexander Kutikov; Steven N Sterious; Robert G Uzzo; Vladimir M Kolenko
Journal:  Urology       Date:  2012-08-28       Impact factor: 2.649

5.  Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression.

Authors:  Zhong Wang; Philip S Lecane; Patricia Thiemann; Qing Fan; Cecilia Cortez; Xuan Ma; Danielle Tonev; Dale Miles; Louie Naumovski; Richard A Miller; Darren Magda; Dong-Gyu Cho; Jonathan L Sessler; Brian L Pike; Samantha M Yeligar; Mazen W Karaman; Joseph G Hacia
Journal:  Mol Cancer       Date:  2007-01-19       Impact factor: 27.401
  5 in total

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