Literature DB >> 11854514

Pim serine/threonine kinases regulate the stability of Socs-1 protein.

X Peter Chen1, Julie A Losman, Simone Cowan, Elizabeth Donahue, Scott Fay, Bao Q Vuong, Martijn C Nawijn, Danielle Capece, Victoria L Cohan, Paul Rothman.   

Abstract

Studies of SOCS-1-deficient mice have implicated Socs-1 in the suppression of JAK-STAT (Janus tyrosine kinase-signal transducers and activators of transcription) signaling and T cell development. It has been suggested that the levels of Socs-1 protein may be regulated through the proteasome pathway. Here we show that Socs-1 interacts with members of the Pim family of serine/threonine kinases in thymocytes. Coexpression of the Pim kinases with Socs-1 results in phosphorylation and stabilization of the Socs-1 protein. The protein levels of Socs-1 are significantly reduced in the Pim-1(-/-), Pim-2(-/-) mice as compared with wild-type mice. Similar to Socs-1(-/-) mice, thymocytes from Pim-1(-/-), Pim-2(-/-) mice showed prolonged Stat6 phosphorylation upon IL-4 stimulation. These data suggest that the Pim kinases may regulate cytokine-induced JAK-STAT signaling through modulation of Socs-1 protein levels.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11854514      PMCID： PMC122338          DOI： 10.1073/pnas.042035699

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

Review 1.  SOCS proteins, regulators of intracellular signaling.

Authors:  X P Chen; J A Losman; P Rothman
Journal:  Immunity       Date:  2000-09       Impact factor: 31.745

2.  IFN-alpha and IFN-gamma have different regulatory effects on IL-4-induced membrane expression of Fc epsilon RIIb and release of soluble Fc epsilon RIIb by human monocytes.

Authors:  A A te Velde; F Rousset; C Peronne; J E De Vries; C G Figdor
Journal:  J Immunol       Date:  1990-04-15       Impact factor: 5.422

3.  Twenty proteins containing a C-terminal SOCS box form five structural classes.

Authors:  D J Hilton; R T Richardson; W S Alexander; E M Viney; T A Willson; N S Sprigg; R Starr; S E Nicholson; D Metcalf; N A Nicola
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-06       Impact factor: 11.205

4.  The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

Authors:  T Durfee; K Becherer; P L Chen; S H Yeh; Y Yang; A E Kilburn; W H Lee; S J Elledge
Journal:  Genes Dev       Date:  1993-04       Impact factor: 11.361

5.  Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines.

Authors:  F Dautry; D Weil; J Yu; A Dautry-Varsat
Journal:  J Biol Chem       Date:  1988-11-25       Impact factor: 5.157

6.  Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells.

Authors:  J Domen; N M van der Lugt; P W Laird; C J Saris; A R Clarke; M L Hooper; A Berns
Journal:  Blood       Date:  1993-09-01       Impact factor: 22.113

7.  Transcriptional induction of pim-1 protein kinase gene expression by interferon gamma and posttranscriptional effects on costimulation with steel factor.

Authors:  M T Yip-Schneider; M Horie; H E Broxmeyer
Journal:  Blood       Date:  1995-06-15       Impact factor: 22.113

8.  Mechanism of interferon-gamma down-regulation of the interleukin 4-induced CD23/Fc epsilon RII expression in human B cells: post-transcriptional modulation by interferon-gamma.

Authors:  C E Lee; S R Yoon; K H Pyun
Journal:  Mol Immunol       Date:  1993-02       Impact factor: 4.407

9.  Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related.

Authors:  M Lilly; T Le; P Holland; S L Hendrickson
Journal:  Oncogene       Date:  1992-04       Impact factor: 9.867

10.  Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

Authors:  N M van der Lugt; J Domen; E Verhoeven; K Linders; H van der Gulden; J Allen; A Berns
Journal:  EMBO J       Date:  1995-06-01       Impact factor: 11.598
View more
  65 in total

1.  Prolactin-regulated pim-1 transcription: identification of critical promoter elements and Akt signaling.

Authors:  Nithya Krishnan; Huiqi Pan; Donna J Buckley; Arthur Buckley
Journal:  Endocrine       Date:  2003 Feb-Mar       Impact factor: 3.633

2.  Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation.

Authors:  Yoo Seob Shin; Katsuyuki Takeda; Yoshiki Shiraishi; Yi Jia; Meiqin Wang; Leila Jackson; A Dale Wright; Laura Carter; John Robinson; Erik Hicken; Erwin W Gelfand
Journal:  Am J Respir Cell Mol Biol       Date:  2011-11-10       Impact factor: 6.914

3.  Detailed analysis of gene expression during development of T cell lineages in the thymus.

Authors:  Nami McCarty; Mari L Shinohara; Linrong Lu; Harvey Cantor
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-09       Impact factor: 11.205

4.  SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.

Authors:  Bao Q Vuong; Teresita L Arenzana; Brian M Showalter; Julie Losman; X Peter Chen; Justin Mostecki; Alexander S Banks; Andre Limnander; Neil Fernandez; Paul B Rothman
Journal:  Mol Cell Biol       Date:  2004-10       Impact factor: 4.272

Review 5.  For better or for worse: the role of Pim oncogenes in tumorigenesis.

Authors:  Martijn C Nawijn; Andrej Alendar; Anton Berns
Journal:  Nat Rev Cancer       Date:  2010-12-09       Impact factor: 60.716

6.  Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.

Authors:  Andrew Mehle; Joao Goncalves; Mariana Santa-Marta; Mark McPike; Dana Gabuzda
Journal:  Genes Dev       Date:  2004-12-01       Impact factor: 11.361

7.  COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.

Authors:  Gabriel N Maine; Xicheng Mao; Christine M Komarck; Ezra Burstein
Journal:  EMBO J       Date:  2006-12-21       Impact factor: 11.598

8.  Pim3 negatively regulates glucose-stimulated insulin secretion.

Authors:  Gregory Vlacich; Martijn C Nawijn; Gene C Webb; Donald F Steiner
Journal:  Islets       Date:  2010-09-01       Impact factor: 2.694

9.  Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation.

Authors:  Teija L T Aho; Riikka J Lund; Emmi K Ylikoski; Sampsa Matikainen; Riitta Lahesmaa; Päivi J Koskinen
Journal:  Immunology       Date:  2005-09       Impact factor: 7.397

10.  Tumor necrosis factor-a augments lipopolysaccharide-induced suppressor of cytokine signalling 3 (SOCS-3) protein expression by preventing the degradation.

Authors:  Jargalsaikhan Dagvadorj; Yoshikazu Naiki; Gantsetseg Tumurkhuu; Abu Shadat Mohammod Noman; Imtiaz Iftakhar-E-Khuda; Takayuki Komatsu; Naoki Koide; Tomoaki Yoshida
Journal:  Immunology       Date:  2010-01       Impact factor: 7.397
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.