Literature DB >> 11854092

Towards a recombinant antigen vaccine against Onchocerca volvulus.

Sara Lustigman1, Eric R James, Wilson Tawe, David Abraham.   

Abstract

Various approaches to identify potential vaccine candidates against onchocerciasis resulted in the cloning of recombinant proteins, which confer protection in vaccinated mice. The development of an effective vaccine against onchocerciasis has been the focus of a research program supported by the Edna McConnell Clark Foundation from 1985 to 1999. The approaches used to clone potential protective antigens and the successful vaccination of animals with some of the antigens are summarized here.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11854092     DOI： 10.1016/s1471-4922(01)02211-5

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  26 in total

1.  Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model.

Authors:  Jessica A Hess; Bin Zhan; Sandra Bonne-Année; Jessica M Deckman; Maria Elena Bottazzi; Peter J Hotez; Thomas R Klei; Sara Lustigman; David Abraham
Journal:  Int J Parasitol       Date:  2014-06-05       Impact factor: 3.981

Review 2.  Onchocerca volvulus: The Road from Basic Biology to a Vaccine.

Authors:  Sara Lustigman; Benjamin L Makepeace; Thomas R Klei; Simon A Babayan; Peter Hotez; David Abraham; Maria Elena Bottazzi
Journal:  Trends Parasitol       Date:  2017-09-22

3.  Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae.

Authors:  Sridhar Arumugam; Junfei Wei; Danielle Ward; David Abraham; Sara Lustigman; Bin Zhan; Thomas R Klei
Journal:  Int J Parasitol       Date:  2014-06-12       Impact factor: 3.981

4.  An antigenic recombinant serine protease from Trichinella spiralis induces protective immunity in BALB/c mice.

Authors:  Xin Li; Jian-ping Yao; Ai-hua Pan; Wei Liu; Xu-chu Hu; Zhong-dao Wu; Xing-wang Zhou
Journal:  Parasitol Res       Date:  2013-07-05       Impact factor: 2.289

5.  DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice.

Authors:  Laura A Kerepesi; Paul B Keiser; Thomas J Nolan; Gerhard A Schad; David Abraham; Thomas B Nutman
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

6.  Insights Into Onchocerca volvulus Population Biology Through Multilocus Immunophenotyping.

Authors:  Carmelle T Norice-Tra; José Ribeiro; Sasisekhar Bennuru; Michael P Fay; Rahul Tyagi; Makedonka Mitreva; Thomas B Nutman
Journal:  J Infect Dis       Date:  2017-09-15       Impact factor: 5.226

7.  In a bovine model of onchocerciasis, protective immunity exists naturally, is absent in drug-cured hosts, and is induced by vaccination.

Authors:  Virginia L Tchakouté; Simon P Graham; Siv Aina Jensen; Benjamin L Makepeace; Charles K Nfon; Leo M Njongmeta; Sara Lustigman; Peter A Enyong; Vincent N Tanya; Albert E Bianco; Alexander J Trees
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-03       Impact factor: 11.205

Review 8.  Helminth infections: the great neglected tropical diseases.

Authors:  Peter J Hotez; Paul J Brindley; Jeffrey M Bethony; Charles H King; Edward J Pearce; Julie Jacobson
Journal:  J Clin Invest       Date:  2008-04       Impact factor: 14.808

Review 9.  The biology and genomics of Strongyloides.

Authors:  M E Viney
Journal:  Med Microbiol Immunol       Date:  2006-03-15       Impact factor: 3.402

10.  The Onchocerca volvulus cysteine proteinase inhibitor, Ov-CPI-2, is a target of protective antibody response that increases with age.

Authors:  Fidelis Cho-Ngwa; Jing Liu; Sara Lustigman
Journal:  PLoS Negl Trop Dis       Date:  2010-08-24
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.