Literature DB >> 18382743

Helminth infections: the great neglected tropical diseases.

Peter J Hotez1, Paul J Brindley, Jeffrey M Bethony, Charles H King, Edward J Pearce, Julie Jacobson.   

Abstract

Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.

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Year:  2008        PMID： 18382743      PMCID： PMC2276811          DOI： 10.1172/JCI34261

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  160 in total

1.  Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference.

Authors:  Patrick J Skelly; Akram Da'dara; Donald A Harn
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2.  Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites.

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Journal:  Nat Med       Date:  2006-07-30       Impact factor: 53.440

3.  Lifting the burden of schistosomiasis--defining elements of infection-associated disease and the benefits of antiparasite treatment.

Authors:  Charles H King
Journal:  J Infect Dis       Date:  2007-07-16       Impact factor: 5.226

Review 4.  Triclabendazole for the treatment of fascioliasis and paragonimiasis.

Authors:  Jennifer Keiser; Dirk Engels; Gottfried Büscher; Jürg Utzinger
Journal:  Expert Opin Investig Drugs       Date:  2005-12       Impact factor: 6.206

5.  The distribution of common intestinal nematodes along an altitudinal transect in KwaZulu-Natal, South Africa.

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Journal:  Ann Trop Med Parasitol       Date:  1996-04

6.  Heterogeneities in the transmission of infectious agents: implications for the design of control programs.

Authors:  M E Woolhouse; C Dye; J F Etard; T Smith; J D Charlwood; G P Garnett; P Hagan; J L Hii; P D Ndhlovu; R J Quinnell; C H Watts; S K Chandiwana; R M Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-07       Impact factor: 11.205

7.  Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys.

Authors:  Thomas W Geisbert; Lisa E Hensley; Peter B Jahrling; Tom Larsen; Joan B Geisbert; Jason Paragas; Howard A Young; Terry M Fredeking; William E Rote; George P Vlasuk
Journal:  Lancet       Date:  2003-12-13       Impact factor: 79.321

8.  Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.

Authors:  Stacey R Dillon; Cindy Sprecher; Angela Hammond; Janine Bilsborough; Maryland Rosenfeld-Franklin; Scott R Presnell; Harald S Haugen; Mark Maurer; Brandon Harder; Janet Johnston; Susan Bort; Sherri Mudri; Joseph L Kuijper; Tom Bukowski; Pamela Shea; Dennis L Dong; Maria Dasovich; Francis J Grant; Luann Lockwood; Steven D Levin; Cosette LeCiel; Kim Waggie; Heather Day; Stavros Topouzis; Janet Kramer; Rolf Kuestner; Zhi Chen; Don Foster; Julia Parrish-Novak; Jane A Gross
Journal:  Nat Immunol       Date:  2004-06-06       Impact factor: 25.606

Review 9.  Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites.

Authors:  Fred D Finkelman; Terez Shea-Donohue; Suzanne C Morris; Lucy Gildea; Richard Strait; Kathleen B Madden; Lisa Schopf; Joseph F Urban
Journal:  Immunol Rev       Date:  2004-10       Impact factor: 12.988

Review 10.  The unacknowledged impact of chronic schistosomiasis.

Authors:  Charles H King; Madeline Dangerfield-Cha
Journal:  Chronic Illn       Date:  2008-03
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  572 in total

1.  Vector-based RNA interference of cathepsin B1 in Schistosoma mansoni.

Authors:  Elissaveta B Tchoubrieva; Poh C Ong; Robert N Pike; Paul J Brindley; Bernd H Kalinna
Journal:  Cell Mol Life Sci       Date:  2010-03-26       Impact factor: 9.261

Review 2.  Developing vaccines to combat hookworm infection and intestinal schistosomiasis.

Authors:  Peter J Hotez; Jeffrey M Bethony; David J Diemert; Mark Pearson; Alex Loukas
Journal:  Nat Rev Microbiol       Date:  2010-11       Impact factor: 60.633

3.  Human U6 promoter drives stronger shRNA activity than its schistosome orthologue in Schistosoma mansoni and human fibrosarcoma cells.

Authors:  Raphaël Duvoisin; Mary A Ayuk; Gabriel Rinaldi; Sutas Suttiprapa; Victoria H Mann; Clarence M Lee; Nicola Harris; Paul J Brindley
Journal:  Transgenic Res       Date:  2011-09-28       Impact factor: 2.788

Review 4.  Macrophage activation governs schistosomiasis-induced inflammation and fibrosis.

Authors:  Luke Barron; Thomas A Wynn
Journal:  Eur J Immunol       Date:  2011-09       Impact factor: 5.532

5.  Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.

Authors:  François Gerbe; Emmanuelle Sidot; Danielle J Smyth; Makoto Ohmoto; Ichiro Matsumoto; Valérie Dardalhon; Pierre Cesses; Laure Garnier; Marie Pouzolles; Bénédicte Brulin; Marco Bruschi; Yvonne Harcus; Valérie S Zimmermann; Naomi Taylor; Rick M Maizels; Philippe Jay
Journal:  Nature       Date:  2016-01-14       Impact factor: 49.962

6.  Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry.

Authors:  Lei Quan; Zhihong Gong; Song Yao; Elisa V Bandera; Gary Zirpoli; Helena Hwang; Michelle Roberts; Gregory Ciupak; Warren Davis; Lara Sucheston; Karen Pawlish; Dana H Bovbjerg; Lina Jandorf; Citadel Cabasag; Jean-Gabriel Coignet; Christine B Ambrosone; Chi-Chen Hong
Journal:  Int J Cancer       Date:  2013-10-08       Impact factor: 7.396

7.  Lessons from bloodless worms: heme homeostasis in C. elegans.

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Journal:  Biometals       Date:  2015-02-28       Impact factor: 2.949

Review 8.  Helminth infections and host immune regulation.

Authors:  Henry J McSorley; Rick M Maizels
Journal:  Clin Microbiol Rev       Date:  2012-10       Impact factor: 26.132

9.  Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes.

Authors:  Andrew R DiNardo; Tomoki Nishiguchi; Emily M Mace; Kimal Rajapakshe; Godwin Mtetwa; Alexander Kay; Gugu Maphalala; W Evan Secor; Rojelio Mejia; Jordan S Orange; Cristian Coarfa; Kapil N Bhalla; Edward A Graviss; Anna M Mandalakas; George Makedonas
Journal:  J Immunol       Date:  2018-05-11       Impact factor: 5.422

10.  Diagnosis of Schistosoma haematobium infection with a mobile phone-mounted Foldscope and a reversed-lens CellScope in Ghana.

Authors:  Richard K D Ephraim; Evans Duah; James S Cybulski; Manu Prakash; Michael V D'Ambrosio; Daniel A Fletcher; Jennifer Keiser; Jason R Andrews; Isaac I Bogoch
Journal:  Am J Trop Med Hyg       Date:  2015-04-27       Impact factor: 2.345
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