| Literature DB >> 11853179 |
Hideaki Matsuda1, Yasuko Ido, Atsushi Hirata, Yoshiaki Ino, Shunsuke Naruto, Tsutomu Amamiya, Michinori Kubo.
Abstract
Antipruritic effects of 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri CUSSON, Umberifferae) were investigated. In mice, an oral administration of CM-ext (200 and 500 mg/kg) inhibited compound 48/80-induced scratching behavior without influence on spontaneous locomotion. Isopimpinellin (3) and osthol (1), coumarin derivatives isolated from CM-ext, showed an inhibitory effect on compound 48/80-induced scratching behavior.Entities:
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Year: 2002 PMID: 11853179 DOI: 10.1248/bpb.25.260
Source DB: PubMed Journal: Biol Pharm Bull ISSN: 0918-6158 Impact factor: 2.233