Literature DB >> 11850622

A gene-driven approach to the identification of ENU mutants in the mouse.

Emma L Coghill1, Alison Hugill, Nick Parkinson, Claire Davison, Peter Glenister, Sian Clements, Jackie Hunter, Roger D Cox, Steve D M Brown.   

Abstract

The construction of parallel archives of DNA and sperm from mice mutagenized with ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome. We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.

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Year:  2002        PMID： 11850622     DOI： 10.1038/ng847

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  58 in total

1.  An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells.

Authors:  Jay L Vivian; Yijing Chen; Della Yee; Elizabeth Schneider; Terry Magnuson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-13       Impact factor: 11.205

2.  Modifier screens in the mouse: time to move forward with reverse genetics.

Authors:  David J Curtis
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-05       Impact factor: 11.205

3.  Efficient target-selected mutagenesis in zebrafish.

Authors:  Erno Wienholds; Freek van Eeden; Marit Kosters; Josine Mudde; Ronald H A Plasterk; Edwin Cuppen
Journal:  Genome Res       Date:  2003-11-12       Impact factor: 9.043

4.  Implementation of the modified-SHIRPA protocol for screening of dominant phenotypes in a large-scale ENU mutagenesis program.

Authors:  Hiroshi Masuya; Maki Inoue; Yumiko Wada; Aya Shimizu; Junko Nagano; Akiko Kawai; Ayako Inoue; Tomoko Kagami; Taeko Hirayama; Ayako Yamaga; Hideki Kaneda; Kimio Kobayashi; Osamu Minowa; Ikuo Miura; Yoichi Gondo; Tetsuo Noda; Shigeharu Wakana; Toshihiko Shiroishi
Journal:  Mamm Genome       Date:  2005-11-11       Impact factor: 2.957

5.  Assessment of a systematic expression profiling approach in ENU-induced mouse mutant lines.

Authors:  Matthias Seltmann; Marion Horsch; Alexei Drobyshev; Yali Chen; Martin Hrabé de Angelis; Johannes Beckers
Journal:  Mamm Genome       Date:  2005-01       Impact factor: 2.957

6.  Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7.

Authors:  Cymbeline T Culiat; Mitchell L Klebig; Zhaowei Liu; Heidi Monroe; Beverly Stanford; Jayashree Desai; Samvit Tandan; Lori Hughes; Marilyn K Kerley; Donald A Carpenter; Dabney K Johnson; Eugene M Rinchik; Qingbo Li
Journal:  Mamm Genome       Date:  2005-08       Impact factor: 2.957

Review 7.  N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express.

Authors:  Sabine P Cordes
Journal:  Microbiol Mol Biol Rev       Date:  2005-09       Impact factor: 11.056

8.  Probabilistic analysis of recessive mutagenesis screen strategies.

Authors:  Jeremy D Silver; Douglas J Hilton; Melanie Bahlo; Benjamin T Kile
Journal:  Mamm Genome       Date:  2007-01-23       Impact factor: 2.957

9.  Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen.

Authors:  Debora Bogani; Catherine Willoughby; Jennifer Davies; Kulvinder Kaur; Ghazala Mirza; Anju Paudyal; Heather Haines; Richard McKeone; Matthew Cadman; Guido Pieles; Jürgen E Schneider; Shoumo Bhattacharya; Andrea Hardy; Patrick M Nolan; Nikos Tripodis; Michael J Depew; Ramya Chandrasekara; Gimara Duncan; Paul T Sharpe; Andy Greenfield; Paul Denny; Steve D M Brown; Jiannis Ragoussis; Ruth M Arkell
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-18       Impact factor: 11.205

10.  Efficient and fast targeted production of murine models based on ENU mutagenesis.

Authors:  M Augustin; R Sedlmeier; T Peters; U Huffstadt; E Kochmann; D Simon; M Schöniger; S Garke-Mayerthaler; J Laufs; M Mayhaus; S Franke; M Klose; A Graupner; M Kurzmann; C Zinser; A Wolf; M Voelkel; M Kellner; M Kilian; S Seelig; A Koppius; A Teubner; D Korthaus; M Nehls; S Wattler
Journal:  Mamm Genome       Date:  2005-06       Impact factor: 2.957
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