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Literature DB >> 11850275

In vitro activities of the des-fluoro(6) Quinolone BMS-284756 against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections.

Ellie J C Goldstein¹, Diane M Citron, C Vreni Merriam, Yumi A Warren, Kerin L Tyrrell, Helen Fernandez.

Abstract

BMS-284756, a new des-fluoro(6) quinolone, was very active against 240 aerobic and 180 anaerobic isolates from bite victims. It inhibited 403 of 420 (96%) isolates, including those of Moraxella spp., CDC group EF-4, and Eikenella corrodens at < or = 2 microg/ml and those of all Pasteurella spp. and Bergeyella zoohelcum at < or = 0.015 microg/ml. Fusobacterium russii and 6 of 11 Fusobacterium nucleatum isolates of animal bite origin were resistant, but isolates of human bite origin were susceptible, which suggests that they were of a different subspecies.

Entities: Chemical Species

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Year: 2002 PMID： 11850275 PMCID： PMC127469 DOI： 10.1128/AAC.46.3.866-870.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. Comparative antianaerobic activity of BMS 284756.

Authors: D B Hoellman; L M Kelly; M R Jacobs; P C Appelbaum
Journal: Antimicrob Agents Chemother Date: 2001-02 Impact factor: 5.191

2. Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756.

Authors: J C Fung-Tomc; B Minassian; B Kolek; E Huczko; L Aleksunes; T Stickle; T Washo; E Gradelski; L Valera; D P Bonner
Journal: Antimicrob Agents Chemother Date: 2000-12 Impact factor: 5.191

3. In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone.

Authors: M Takahata; J Mitsuyama; Y Yamashiro; M Yonezawa; H Araki; Y Todo; S Minami; Y Watanabe; H Narita
Journal: Antimicrob Agents Chemother Date: 1999-05 Impact factor: 5.191

Review 4. New horizons in the bacteriology, antimicrobial susceptibility and therapy of animal bite wounds.

Authors: E J Goldstein
Journal: J Med Microbiol Date: 1998-02 Impact factor: 2.472

5. Evaluation of the RapID CB Plus system for identification of Corynebacterium species and other gram-positive rods.

Authors: M K Hudspeth; S Hunt Gerardo; D M Citron; E J Goldstein
Journal: J Clin Microbiol Date: 1998-02 Impact factor: 5.948

6. Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens.

Authors: E J Goldstein; D M Citron; M Hudspeth; S Hunt Gerardo; C V Merriam
Journal: J Antimicrob Chemother Date: 1998-03 Impact factor: 5.790

7. In vitro activity of Bay 12-8039, a new 8-methoxyquinolone, compared to the activities of 11 other oral antimicrobial agents against 390 aerobic and anaerobic bacteria isolated from human and animal bite wound skin and soft tissue infections in humans.

Authors: E J Goldstein; D M Citron; M Hudspeth; S Hunt Gerardo; C V Merriam
Journal: Antimicrob Agents Chemother Date: 1997-07 Impact factor: 5.191

Review 8. Bite wounds and infection.

Authors: E J Goldstein
Journal: Clin Infect Dis Date: 1992-03 Impact factor: 9.079

9. Characterization of saccharolytic Bacteroides and Prevotella isolates from infected dog and cat bite wounds in humans.

Authors: C J Alexander; D M Citron; S Hunt Gerardo; M C Claros; D Talan; E J Goldstein
Journal: J Clin Microbiol Date: 1997-02 Impact factor: 5.948

In vitro activities of the des-fluoro(6) Quinolone BMS-284756 against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections.

1. Comparative antianaerobic activity of BMS 284756.

2. Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756.

3. In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone.

Review 4. New horizons in the bacteriology, antimicrobial susceptibility and therapy of animal bite wounds.

5. Evaluation of the RapID CB Plus system for identification of Corynebacterium species and other gram-positive rods.

6. Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens.

7. In vitro activity of Bay 12-8039, a new 8-methoxyquinolone, compared to the activities of 11 other oral antimicrobial agents against 390 aerobic and anaerobic bacteria isolated from human and animal bite wound skin and soft tissue infections in humans.

Review 8. Bite wounds and infection.

9. Characterization of saccharolytic Bacteroides and Prevotella isolates from infected dog and cat bite wounds in humans.

10. Bacteriologic analysis of infected dog and cat bites. Emergency Medicine Animal Bite Infection Study Group.

1. Time-kill studies of the antianaerobe activity of garenoxacin compared with those of nine other agents.

2. Postoperative care of the facial laceration.

3. Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.

4. New drugs to treat skin and soft tissue infections.

5. In vitro activities of a new des-fluoro(6) quinolone, garenoxacin, against clinical anaerobic bacteria.

6. In vitro activities of garenoxacin (BMS-284756) against 170 clinical isolates of nine Pasteurella species.