Literature DB >> 11844697

Beta-carboline-carbohydrate hybrids: molecular design, chemical synthesis and evaluation of novel DNA photocleavers.

Kazunobu Toshima1, Yukiko Okuno, Yoko Nakajima, Shuichi Matsumura.   

Abstract

Beta-carboline present in beta-carboline alkaloids from marine organisms was found, for the first time, to cleave DNA at the guanine site upon irradiation with UV light with a long wavelength without any additive, and beta-carboline-carbohydrate hybrid system was effective for DNA cleavage.

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Year:  2002        PMID： 11844697     DOI： 10.1016/s0960-894x(01)00828-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis of the carboline disaccharide domain of shishijimicin A.

Authors:  K C Nicolaou; J L Kiappes; Weiwei Tian; Vijaya B Gondi; Jochen Becker
Journal:  Org Lett       Date:  2011-06-28       Impact factor: 6.005

2.  Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy.

Authors:  Xinran Geng; Yichang Ren; Fangfang Wang; Danmei Tian; Xinsheng Yao; Youwei Zhang; Jinshan Tang
Journal:  Biochem Biophys Res Commun       Date:  2018-03-01       Impact factor: 3.575

Review 3.  β-Carboline-based molecular hybrids as anticancer agents: a brief sketch.

Authors:  Jay Prakash Soni; Yogesh Yeole; Nagula Shankaraiah
Journal:  RSC Med Chem       Date:  2021-03-24
  3 in total

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