| Literature DB >> 11835383 |
Vincenzo Bonifati1, Guido J Breedveld, Ferdinando Squitieri, Nicola Vanacore, Pierluigi Brustenghi, Biswadjiet S Harhangi, Pasquale Montagna, Milena Cannella, Giovanni Fabbrini, Patrizia Rizzu, Cornelia M van Duijn, Ben A Oostra, Giuseppe Meco, Peter Heutink.
Abstract
Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.Entities:
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Year: 2002 PMID： 11835383 DOI： 10.1002/ana.10106
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422