| Literature DB >> 11834592 |
D J Nicholl1, J R Vaughan, N L Khan, S L Ho, D E W Aldous, S Lincoln, M Farrer, J D Gayton, M B Davis, P Piccini, S E Daniel, G G Lennox, D J Brooks, A C Williams, N W Wood.
Abstract
We present the findings of a study of two large unrelated kindreds with autosomal dominant Parkinson's disease. The affected members were assessed clinically and with [(18)F]6-fluorodopa-PET and were indistinguishable from patients with the sporadic form of Parkinson's disease. In one kindred, an affected member was examined subsequently at autopsy and Lewy bodies were present in a distribution typical of sporadic Parkinson's disease. These kindreds are distinct from other Parkinsonian kindreds with identified genetic loci (PARK1-4) and provide further evidence for genetic heterogeneity in familial Parkinson's disease.Entities:
Mesh：
Year: 2002 PMID： 11834592 DOI： 10.1093/brain/awf013
Source DB: PubMed Journal: Brain ISSN： 0006-8950 Impact factor: 13.501