| Literature DB >> 11833004 |
Solveig Gretarsdottir1, Sigurlaug Sveinbjörnsdottir, Hjörtur H Jonsson, Finnbogi Jakobsson, Elisabet Einarsdottir, Uggi Agnarsson, Dana Shkolny, Gisli Einarsson, Herdis M Gudjonsdottir, Einar M Valdimarsson, Olafur B Einarsson, Gudmundur Thorgeirsson, Radinka Hadzic, Sif Jonsdottir, Sigridur Th Reynisdottir, Sigrun M Bjarnadottir, Thorunn Gudmundsdottir, Gudrun J Gudlaugsdottir, Ramanjit Gill, Klaus Lindpaintner, Jesus Sainz, Helgi H Hannesson, Gunnar Th Sigurdsson, Michael L Frigge, Augustine Kong, Vilmundur Gudnason, Kari Stefansson, Jeffrey R Gulcher.
Abstract
Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9 x 10(-6)). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as "STRK1," does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke.Entities:
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Year: 2002 PMID： 11833004 PMCID： PMC384939 DOI： 10.1086/339252
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025