Wenzhao Liang1, Dezhi Zhang2, Jing Mang1, Jinting He1, Hongyu Liu1, Yankun Shao1, Fanglei Han3, Zhongxin Xu1. 1. Department of Neurology, China-Japan Union Hospital of Jilin University Changchun, China. 2. Department of Abdomen Ultrasound, The First Hospital of Jilin University Changchun, China. 3. Department of Anesthesiology, China-Japan Union hospital of Jilin University Changchun, China.
Abstract
BACKGROUND AND PURPOSE: Data on the association between PDE4D SNP 87 and the risk of ischemic stroke are contentious and debatable. The present meta-analysis was undertaken to systematically summarize the possible association. METHODS: Based on comprehensive search of PubMed, Embase, and CNKI databases, we identified 18 eligible articles examining the relationship between PDE4D SNP 87 and ischemic stroke risk. We evaluated the strength of relationship using odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: In the overall analysis, PDE4D SNP 87 was not found to have effects on the risk of ischemic stroke. The null association persisted in the subgroup analyses according to ethnicity and sample size. CONCLUSIONS: Our meta-analysis suggests that PDE4D SNP 87 may not represent an independent risk factor for ischemic stroke development.
BACKGROUND AND PURPOSE: Data on the association between PDE4D SNP 87 and the risk of ischemic stroke are contentious and debatable. The present meta-analysis was undertaken to systematically summarize the possible association. METHODS: Based on comprehensive search of PubMed, Embase, and CNKI databases, we identified 18 eligible articles examining the relationship between PDE4D SNP 87 and ischemic stroke risk. We evaluated the strength of relationship using odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: In the overall analysis, PDE4D SNP 87 was not found to have effects on the risk of ischemic stroke. The null association persisted in the subgroup analyses according to ethnicity and sample size. CONCLUSIONS: Our meta-analysis suggests that PDE4D SNP 87 may not represent an independent risk factor for ischemic stroke development.
Authors: J M Staton; M S Sayer; G J Hankey; J Attia; A Thakkinstian; Q Yi; V J Cole; R Baker; J W Eikelboom Journal: J Neurol Neurosurg Psychiatry Date: 2006-09 Impact factor: 10.154
Authors: Laura Ponsaerts; Lotte Alders; Melissa Schepers; Rúbia Maria Weffort de Oliveira; Jos Prickaerts; Tim Vanmierlo; Annelies Bronckaers Journal: Biomedicines Date: 2021-06-22