Literature DB >> 11828433

Circe effect versus enzyme preorganization: what can be learned from the structure of the most proficient enzyme?

A Warshel1, J Florián, M Strajbl, J Villà.   

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Year:  2001        PMID： 11828433     DOI： 10.1002/1439-7633(20010202)2:2<109::AID-CBIC109>3.0.CO;2-9

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  16 in total

1.  Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase.

Authors:  Ayse Hacisalihoglu; Peter Panizzi; Paul E Bock; Rodney M Camire; Sriram Krishnaswamy
Journal:  J Biol Chem       Date:  2007-09-11       Impact factor: 5.157

2.  Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site.

Authors:  Vanessa Iiams; Bijoy J Desai; Alexander A Fedorov; Elena V Fedorov; Steven C Almo; John A Gerlt
Journal:  Biochemistry       Date:  2011-09-06       Impact factor: 3.162

3.  Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent.

Authors:  Wing-Yin Tsang; B McKay Wood; Freeman M Wong; Weiming Wu; John A Gerlt; Tina L Amyes; John P Richard
Journal:  J Am Chem Soc       Date:  2012-08-21       Impact factor: 15.419

4.  Electrostatic stabilization in a pre-organized polar active site: the catalytic role of Lys-80 in Candida tenuis xylose reductase (AKR2B5) probed by site-directed mutagenesis and functional complementation studies.

Authors:  Regina Kratzer; Bernd Nidetzky
Journal:  Biochem J       Date:  2005-07-15       Impact factor: 3.857

5.  Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase.

Authors:  Masahiro Fujihashi; Toyokazu Ishida; Shingo Kuroda; Lakshmi P Kotra; Emil F Pai; Kunio Miki
Journal:  J Am Chem Soc       Date:  2013-11-11       Impact factor: 15.419

6.  Using catalytic atom maps to predict the catalytic functions present in enzyme active sites.

Authors:  Geoffrey R Nosrati; K N Houk
Journal:  Biochemistry       Date:  2012-08-30       Impact factor: 3.162

7.  Ground state destabilization from a positioned general base in the ketosteroid isomerase active site.

Authors:  Eliza A Ruben; Jason P Schwans; Matthew Sonnett; Aditya Natarajan; Ana Gonzalez; Yingssu Tsai; Daniel Herschlag
Journal:  Biochemistry       Date:  2013-01-30       Impact factor: 3.162

8.  QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis.

Authors:  Courtney L Stanton; I-Feng W Kuo; Christopher J Mundy; Teodoro Laino; K N Houk
Journal:  J Phys Chem B       Date:  2007-10-10       Impact factor: 2.991

9.  Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase.

Authors:  John D Phillips; Frank G Whitby; James P Kushner; Christopher P Hill
Journal:  EMBO J       Date:  2003-12-01       Impact factor: 11.598

10.  Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.

Authors:  Hao Hu; Amy Boone; Weitao Yang
Journal:  J Am Chem Soc       Date:  2008-10-08       Impact factor: 15.419
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