Literature DB >> 11828382

Strategies for engineering human chromosomes with therapeutic potential.

Richard Saffery1, K H Andy Choo.   

Abstract

Human engineered chromosomes (HECs) have several potential advantages over currently used vectors for gene therapy applications. Firstly, there is no upper size limit to DNA that can be cloned in these vectors. Secondly, their extrachromosomal nature ensures that introduced genes are neither disruptive to, nor affected by, the genome of the host cell. Finally, being solely human in origin, HEC vectors should not evoke adverse host immunogenic responses. Recent advances have produced a variety of HECs via several different approaches. This review focuses on the current methodologies for making HEC vectors, the advantages and problems associated with each strategy, and discusses the outlook for HEC vectors as ex vivo therapeutic agents. Copyright 2001 John Wiley & Sons, Ltd.

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Year:  2002        PMID： 11828382     DOI： 10.1002/jgm.236

Source DB:  PubMed          Journal:  J Gene Med        ISSN： 1099-498X            Impact factor:   4.565


  15 in total

Review 1.  Microcell-mediated chromosome transfer (MMCT): small cells with huge potential.

Authors:  Aideen M O Doherty; Elizabeth M C Fisher
Journal:  Mamm Genome       Date:  2003-09       Impact factor: 2.957

Review 2.  Artificial and engineered chromosomes: developments and prospects for gene therapy.

Authors:  Brenda R Grimes; Zoia Larin Monaco
Journal:  Chromosoma       Date:  2005-10-15       Impact factor: 4.316

3.  Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome.

Authors:  Hidetoshi Yamada; Atsushi Kunisato; Masahiro Kawahara; Candice G T Tahimic; Xianying Ren; Hiroshi Ueda; Teruyuki Nagamune; Motonobu Katoh; Toshiaki Inoue; Mitsuo Nishikawa; Mitsuo Oshimura
Journal:  J Hum Genet       Date:  2005-12-07       Impact factor: 3.172

Review 4.  Human artificial chromosomes for gene delivery and the development of animal models.

Authors:  Yasuhiro Kazuki; Mitsuo Oshimura
Journal:  Mol Ther       Date:  2011-07-12       Impact factor: 11.454

Review 5.  Using human artificial chromosomes to study centromere assembly and function.

Authors:  Oscar Molina; Natalay Kouprina; Hiroshi Masumoto; Vladimir Larionov; William C Earnshaw
Journal:  Chromosoma       Date:  2017-07-07       Impact factor: 4.316

Review 6.  The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer.

Authors:  Karen J Meaburn; Christopher N Parris; Joanna M Bridger
Journal:  Chromosoma       Date:  2005-10-15       Impact factor: 4.316

Review 7.  Minichromosomes and artificial chromosomes in Arabidopsis.

Authors:  Minoru Murata
Journal:  Chromosome Res       Date:  2014-06       Impact factor: 5.239

Review 8.  A new generation of human artificial chromosomes for functional genomics and gene therapy.

Authors:  Natalay Kouprina; William C Earnshaw; Hiroshi Masumoto; Vladimir Larionov
Journal:  Cell Mol Life Sci       Date:  2012-08-21       Impact factor: 9.261

9.  Modulation of immune responses to bovine herpesvirus-1 in cattle by immunization with a DNA vaccine encoding glycoprotein D as a fusion protein with bovine CD154.

Authors:  Sharmila Manoj; Philip J Griebel; Lorne A Babiuk; Sylvia van Drunen Littel-van den Hurk
Journal:  Immunology       Date:  2004-06       Impact factor: 7.397

10.  Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion.

Authors:  Hidetoshi Yamada; Yanze C Li; Mitsuo Nishikawa; Mitsuo Oshimura; Toshiaki Inoue
Journal:  J Hum Genet       Date:  2008-03-06       Impact factor: 3.172
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