| Literature DB >> 11827034 |
Y Sugie1, H Hirai, H Kachi-Tonai, Y J Kim, Y Kojima, Y Shiomi, A Sugiura, A Sugiura, Y Suzuki, N Yoshikawa, L Brennan, J Duignan, L H Huang, J Sutcliffe, N Kojima.
Abstract
Two new antibiotics, CJ-16,264 (I) and CJ-16,367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and some Gram-negative strains such as Moraxella catarrhalis and Escherichia coli with altered permeability (imp). Comparison of an antibacterial profile between the two compounds suggested that the gamma-lactone portion of I is important for the activity.Entities:
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Year: 2001 PMID： 11827034 DOI： 10.7164/antibiotics.54.917
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649