Literature DB >> 1182534

Sleep cycle control and cholinergic mechanisms: differential effects of carbachol injections at pontine brain stem sites.

T T Amatruda, D A Black, T M McKenna, R W McCarley, J A Hobson.   

Abstract

Muscular atonia and cortical desynchronization, two signs of desynchronized sleep, can be enhanced or suppressed by direct injection of carbachol into the pontine brain stem of cats. The positive effects are graded, being maximal in the gigantocellular tegmental field and less marked in adjacent nuclei. These positive effects are dose-dependent. Suppressive effects of carbachol are maximal in the region of the locus coeruleus and are dose-dependent but do not exceed those of the vehicle alone. The results support the hypothesis that cholinergic mechanisms of the pontine tegmentum are involved in desynchronized sleep generation.

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Year:  1975        PMID： 1182534     DOI： 10.1016/0006-8993(75)90369-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  25 in total

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3.  The influence of respiration on brainstem and cardiovagal response to auricular vagus nerve stimulation: A multimodal ultrahigh-field (7T) fMRI study.

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Review 4.  Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence.

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Review 5.  The pontine REM switch: past and present.

Authors:  Patrick M Fuller; Clifford B Saper; Jun Lu
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6.  Physostigmine alters onset but not duration of REM sleep in man.

Authors:  J C Gillin; N Sitaram; W B Mendelson; R J Wyatt
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7.  Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep.

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Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-29       Impact factor: 11.205

8.  Modulation of desynchronized sleep through microinjection of beta-adrenergic agonists and antagonists in the dorsal pontine tegmentum of the cat.

Authors:  G Tononi; M Pompeiano; O Pompeiano
Journal:  Pflugers Arch       Date:  1989-11       Impact factor: 3.657

Review 9.  The cognitive neuroscience of lucid dreaming.

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10.  State-dependent control of lumbar motoneurons by the hypocretinergic system.

Authors:  Jack Yamuy; Simon J Fung; Mingchu Xi; Michael H Chase
Journal:  Exp Neurol       Date:  2009-12-03       Impact factor: 5.330
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