| Literature DB >> 25548191 |
Christa J Van Dort1, Daniel P Zachs2, Jonathan D Kenny2, Shu Zheng3, Rebecca R Goldblum4, Noah A Gelwan2, Daniel M Ramos5, Michael A Nolan4, Karen Wang5, Feng-Ju Weng6, Yingxi Lin6, Matthew A Wilson5, Emery N Brown7.
Abstract
Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selective optogenetic activation of cholinergic neurons in the PPT or LDT during non-REM (NREM) sleep increased the number of REM sleep episodes and did not change REM sleep episode duration. Activation of cholinergic neurons in the PPT or LDT during NREM sleep was sufficient to induce REM sleep.Entities:
Keywords: acetylcholine; mesopontine tegmentum; mouse; optogenetics; rapid eye movement sleep
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Year: 2014 PMID： 25548191 PMCID： PMC4299243 DOI： 10.1073/pnas.1423136112
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205