OBJECTIVE: To determine the relative importance of environmental and genetic effects in the development of rheumatoid arthritis. DESIGN: Historical cohort study with record linkage between a twin registry and the Danish discharge registry as well as the Danish national registry of deaths used to estimate completeness. SETTING: Two population based nationwide twin birth cohorts. PARTICIPANTS: 37 338 twins were sent a questionnaire about rheumatic diseases. Self reported rheumatoid arthritis was verified by clinical examination and from medical records. MAIN OUTCOME MEASURES: The probandwise concordance rate of rheumatoid arthritis in monozygotic and dizygotic twins. RESULTS: The response rate was 84.7%. Rheumatoid arthritis was verified in 13 monozygotic and 36 dizygotic twins. There were no concordant monozygotic twin pairs and two concordant dizygotic twin pairs. Based on capture-recapture methods the probability of ascertainment was 78.3%. The probandwise concordance rate was 0 (95% confidence interval 0 to 24.7) in monozygotic twins and 8.8 (1.9 to 23.7) in dizygotic twins. CONCLUSION: Genes are of minor importance in the development of rheumatoid arthritis.
OBJECTIVE: To determine the relative importance of environmental and genetic effects in the development of rheumatoid arthritis. DESIGN: Historical cohort study with record linkage between a twin registry and the Danish discharge registry as well as the Danish national registry of deaths used to estimate completeness. SETTING: Two population based nationwide twin birth cohorts. PARTICIPANTS: 37 338 twins were sent a questionnaire about rheumatic diseases. Self reported rheumatoid arthritis was verified by clinical examination and from medical records. MAIN OUTCOME MEASURES: The probandwise concordance rate of rheumatoid arthritis in monozygotic and dizygotic twins. RESULTS: The response rate was 84.7%. Rheumatoid arthritis was verified in 13 monozygotic and 36 dizygotic twins. There were no concordant monozygotic twin pairs and two concordant dizygotic twin pairs. Based on capture-recapture methods the probability of ascertainment was 78.3%. The probandwise concordance rate was 0 (95% confidence interval 0 to 24.7) in monozygotic twins and 8.8 (1.9 to 23.7) in dizygotic twins. CONCLUSION: Genes are of minor importance in the development of rheumatoid arthritis.
Authors: A S Rigby; A J Silman; L Voelm; J C Gregory; W E Ollier; M A Khan; G T Nepom; G Thomson Journal: Genet Epidemiol Date: 1991 Impact factor: 2.135
Authors: D Jawaheer; M F Seldin; C I Amos; W V Chen; R Shigeta; J Monteiro; M Kern; L A Criswell; S Albani; J L Nelson; D O Clegg; R Pope; H W Schroeder ; S L Bridges ; D S Pisetsky; R Ward; D L Kastner; R L Wilder; T Pincus; L F Callahan; D Flemming; M H Wener; P K Gregersen Journal: Am J Hum Genet Date: 2001-03-09 Impact factor: 11.025
Authors: Chang-Fu Kuo; Matthew J Grainge; Ana M Valdes; Lai-Chu See; Kuang-Hui Yu; S W Steven Shaw; Shue-Fen Luo; Weiya Zhang; Michael Doherty Journal: Rheumatology (Oxford) Date: 2017-06-01 Impact factor: 7.580