Jose U Scher1, Walter A Bretz, Steven B Abramson. 1. aDivision of Rheumatology and Microbiome Center for Rheumatology and Autoimmunity, New York University Hospital for Joint Diseases bDivision of Rheumatology and Department of Medicine, New York University School of Medicine cDepartment of Cariology and Comprehensive Care, New York University College of Dentistry, New York, New York, USA *Jose U. Scher and Walter A. Bretz contributed equally to this work.
Abstract
PURPOSE OF REVIEW: Since the early 1900s, the role of periodontal disease in the pathogenesis of rheumatoid arthritis has been a matter of intense research. The last decade has witnessed many advances supporting a link between periodontitis, the presence of specific bacterial species (i.e. Porphyromonas gingivalis) and their effects in immune response. This review will examine available evidence on the individuals. RECENT FINDINGS: Epidemiological studies have stressed the commonalities shared by periodontal disease and rheumatoid arthritis. Many groups have focused their attention toward understanding the periodontal microbiota and its alterations in states of health and disease. The presence of circulating antibodies against periodontopathic bacteria and associated inflammatory response has been found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. Most recently, the periodontal microbiota of smokers and patients with RA has been elucidated, revealing profound changes in the bacterial communities compared with those of healthy controls. This has led to several small clinical trials of progressive disease treatment as adjuvant for disease-modifying therapy in RA. SUMMARY: Smoking and periodontal disease are emerging risk factors for the development of RA. Epidemiological, clinical, and basic research has further strengthened this association, pointing toward changes in the oral microbiota as possible contributors to systemic inflammation and arthritis.
PURPOSE OF REVIEW: Since the early 1900s, the role of periodontal disease in the pathogenesis of rheumatoid arthritis has been a matter of intense research. The last decade has witnessed many advances supporting a link between periodontitis, the presence of specific bacterial species (i.e. Porphyromonas gingivalis) and their effects in immune response. This review will examine available evidence on the individuals. RECENT FINDINGS: Epidemiological studies have stressed the commonalities shared by periodontal disease and rheumatoid arthritis. Many groups have focused their attention toward understanding the periodontal microbiota and its alterations in states of health and disease. The presence of circulating antibodies against periodontopathic bacteria and associated inflammatory response has been found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. Most recently, the periodontal microbiota of smokers and patients with RA has been elucidated, revealing profound changes in the bacterial communities compared with those of healthy controls. This has led to several small clinical trials of progressive disease treatment as adjuvant for disease-modifying therapy in RA. SUMMARY: Smoking and periodontal disease are emerging risk factors for the development of RA. Epidemiological, clinical, and basic research has further strengthened this association, pointing toward changes in the oral microbiota as possible contributors to systemic inflammation and arthritis.
Authors: Cynthia Savioli; Ana Cristina M Ribeiro; Gisele Maria Campos Fabri; Ana Luisa Calich; Jozélio Carvalho; Clovis A Silva; Vilma S T Viana; Eloísa Bonfá; José Tadeu T Siqueira Journal: J Clin Rheumatol Date: 2012-06 Impact factor: 3.517
Authors: Sílvia R L Teixeira; Flávia Mattarazo; Magda Feres; Luciene C Figueiredo; Marcelo de Faveri; Maria R L Simionato; Marcia P A Mayer Journal: J Clin Periodontol Date: 2009-06 Impact factor: 8.728
Authors: Scott N Peterson; Erik Snesrud; Jia Liu; Ana C Ong; Mogens Kilian; Nicholas J Schork; Walter Bretz Journal: PLoS One Date: 2013-03-08 Impact factor: 3.240
Authors: Judith Kelsen; Kyle Bittinger; Helen Pauly-Hubbard; Leah Posivak; Stephanie Grunberg; Robert Baldassano; James D Lewis; Gary D Wu; Frederic D Bushman Journal: Inflamm Bowel Dis Date: 2015-12 Impact factor: 5.325
Authors: M Yamakawa; K Ouhara; M Kajiya; S Munenaga; M Kittaka; S Yamasaki; K Takeda; K Takeshita; N Mizuno; T Fujita; E Sugiyama; H Kurihara Journal: Clin Exp Immunol Date: 2016-08-29 Impact factor: 4.330
Authors: Leena Äyräväinen; Anna Maria Heikkinen; Antti Kuuliala; Kirsi Ahola; Riitta Koivuniemi; Jaakko Peltola; Anni Suomalainen; Eeva Moilanen; Mari Hämäläinen; Leena Laasonen; Jukka H Meurman; Marjatta Leirisalo-Repo Journal: Rheumatol Int Date: 2018-07-24 Impact factor: 2.631