T Claudi1, J G Cooper. 1. Rønvik Health Centre, Bodø, Norway. tclaudi@online.no
Abstract
OBJECTIVE: To evaluate whether measurement of albumin creatinine ratio (ACR) on a spot urine specimen can replace a timed overnight collection of urine albumin excretion rate (UAER) in patients with diabetes in primary care. DESIGN: Patients with diabetes attending Rønvik Health Centre were asked to bring a timed overnight collection of urine for measurement of UAER. They were also asked to void a urine specimen for measurement of albumin creatinine ratio. SETTING: Primary health care. SUBJECTS: One-hundred-and-six persons with diabetes (47 women, 59 men) aged 13 to 78 years. RESULTS: The sensitivity and specificity of ACR with cut-off values of 2.5 mg/mmol for men and 3.5 mg/mmol for women compared to UAER with cut-off value of 20 mg/24 h was 90%. CONCLUSIONS: Spot urine ACR analysed on a DCA 2000 can replace a timed (overnight) collection of urine and measurement of UAER when diabetic patients are reviewed in general practice. This simplifies procedures for the patient as a timed urine collection is no longer necessary. Another advantage is that the results are available after 7 min.
OBJECTIVE: To evaluate whether measurement of albumin creatinine ratio (ACR) on a spot urine specimen can replace a timed overnight collection of urine albumin excretion rate (UAER) in patients with diabetes in primary care. DESIGN:Patients with diabetes attending Rønvik Health Centre were asked to bring a timed overnight collection of urine for measurement of UAER. They were also asked to void a urine specimen for measurement of albumin creatinine ratio. SETTING: Primary health care. SUBJECTS: One-hundred-and-six persons with diabetes (47 women, 59 men) aged 13 to 78 years. RESULTS: The sensitivity and specificity of ACR with cut-off values of 2.5 mg/mmol for men and 3.5 mg/mmol for women compared to UAER with cut-off value of 20 mg/24 h was 90%. CONCLUSIONS: Spot urine ACR analysed on a DCA 2000 can replace a timed (overnight) collection of urine and measurement of UAER when diabeticpatients are reviewed in general practice. This simplifies procedures for the patient as a timed urine collection is no longer necessary. Another advantage is that the results are available after 7 min.
Authors: Sharon H Saydah; Meda E Pavkov; Cindy Zhang; David A Lacher; Mark S Eberhardt; Nilka Rios Burrows; Andrew S Narva; Paul W Eggers; Desmond E Williams Journal: Clin Chem Date: 2013-01-11 Impact factor: 8.327