Literature DB >> 11819440

Pathogenic effects of Opolysaccharide from Shigella flexneri strain.

Qi-Ping Zhong.   

Abstract

AIM:To investigate the specific pathogenesis of O-polysaccharide (O-PS) which is on the outer membrane of lipopolysaccharides (LPS) from Shigella flexneri.
METHODS: The O-PS was isolated and purified from Shigella flexneri 5 M90T by enzymatic hydrolysis and gel chromatography. Effects of O-PS were observed by in vitro experiment, (HeLa cell culture), and in vivo experiment (rabbit ileal loop assay).
RESULTS: In vitro and in vivo experiments with the purified O-PS from Shigella flexneri revealed that the O-PS alone was toxic to Hela cells and caused mucosal inflammation and hemorrhagic exudation in ileal loop of rabbit.DISCUSSION:O-PS might be one of the factors causing diarrhea and its mechanism was different from endotoxin reaction of LPS.The molecular mechanism of O-PS need further studies.

Entities:  

Year:  1999        PMID： 11819440      PMCID： PMC4688479          DOI： 10.3748/wjg.v5.i3.245

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  7 in total

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Journal:  Rev Infect Dis       Date:  1991 Mar-Apr

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Authors:  K Rajakumar; B H Jost; C Sasakawa; N Okada; M Yoshikawa; B Adler
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Journal:  Microbiology       Date:  1994-09       Impact factor: 2.777

7.  Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane.

Authors:  R C Sandlin; K A Lampel; S P Keasler; M B Goldberg; A L Stolzer; A T Maurelli
Journal:  Infect Immun       Date:  1995-01       Impact factor: 3.441
  7 in total
  7 in total

1.  Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.

Authors:  H L Weng; W M Cai; R H Liu
Journal:  World J Gastroenterol       Date:  2001-02       Impact factor: 5.742

2.  Distribution of nitric oxide synthase in stomach myenteric plexus of rats.

Authors:  X Peng; J B Feng; H Yan; Y Zhao; S L Wang
Journal:  World J Gastroenterol       Date:  2001-12       Impact factor: 5.742

Review 3.  Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.

Authors:  Gunnar N Schroeder; Hubert Hilbi
Journal:  Clin Microbiol Rev       Date:  2008-01       Impact factor: 26.132

4.  Identification of alkA gene related to virulence of Shigella flexneri 2a by mutational analysis.

Authors:  Zhao-Xing Shi; Heng-Liang Wang; Kun Hu; Er-Ling Feng; Xiao Yao; Guo-Fu Su; Pei-Tang Huang; Liu-Yu Huang
Journal:  World J Gastroenterol       Date:  2003-12       Impact factor: 5.742

5.  Identification of RanBMP interacting with Shigella flexneri IpaC invasin by two-hybrid system of yeast.

Authors:  Xiao Yao; Heng-Liang Wang; Zhao-Xing Shi; Xiao-Yu Yan; Er-Ling Feng; Bo-Lun Yang; Liu-Yu Huang
Journal:  World J Gastroenterol       Date:  2003-06       Impact factor: 5.742

6.  Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a.

Authors:  Huan Nie; Fan Yang; Xiaobing Zhang; Jian Yang; Lihong Chen; Jing Wang; Zhaohui Xiong; Junping Peng; Lilian Sun; Jie Dong; Ying Xue; Xingye Xu; Shuxia Chen; Zhijian Yao; Yan Shen; Qi Jin
Journal:  BMC Genomics       Date:  2006-07-06       Impact factor: 3.969

7.  RNA-seq analysis of the influence of anaerobiosis and FNR on Shigella flexneri.

Authors:  Marta Vergara-Irigaray; Maria C Fookes; Nicholas R Thomson; Christoph M Tang
Journal:  BMC Genomics       Date:  2014-06-06       Impact factor: 3.969
  7 in total

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